Lesion size on ultrasonography predicts potential invasion in ductal carcinoma in situ preoperatively diagnosed by breast needle biopsy

Kyoko Shimoyama, Tomo Osako, Toshiharu Mitsuhashi, Futoshi Akiyama, Takuji Iwase

Research output: Contribution to journalArticlepeer-review

Abstract

Ductal carcinoma in situ (DCIS) of the breast has no potential to metastasize, but over 20% of cases preoperatively diagnosed as DCIS are upstaged on final pathology. The rates of upstaging and the predictors for invasion on final pathology were evaluated. For 240 primary breast cancers, radiological findings on mammography, ultrasonography, and magnetic resonance imaging were investigated along with pathological and clinical information. Univariate and multivariate analyses were performed to identify predictors of potential invasion. Of the 240 breast cancers, 68 (28.3%) showed invasion on final pathology, and 5 (2.5%) had sentinel node metastasis. The multivariate analysis identified five independent predictors: non-mass lesions > 2.4 cm on ultrasonography (odds ratio [OR] 2.84, 95% confidence interval [CI] 1.02-7.95, p=0.047), comedo-type histology (OR 6.89, 95% CI 1.89-25.08, p < 0.01), solid-type histology (OR 7.97, 95% CI 2.08-30.49, p < 0.01), palpable mass (OR 2.63, 95% CI 1.05-6.64, p=0.04), and bloody nipple discharge (OR 4.61, 95% CI 1.20-17.66, p=0.02). These five predictors were associated with invasion on final pathology and may help select candidates for sentinel node biopsy.

Original languageEnglish
Pages (from-to)233-240
Number of pages8
JournalActa medica Okayama
Volume71
Issue number3
Publication statusPublished - 2017

Keywords

  • Breast cancer
  • Breast needle biopsy
  • DCIS
  • Imaging examination
  • Sentinel node biopsy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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