Abstract
Induction of xenobiotics metabolizing enzymes is related to the formation and chemoprevention of cancer. Since cytochrome P450s (CYPs) including CYP1A subfamily metabolize certain pro-carcinogens to their ultimate forms, down-regulation of CYP1As by food factors leads to the prevention of cancer. Mushroom polysaccharides, especially β-glucans such as lentinan from Lentinus edodes, possess the anti-tumor and immunomodulating activities through the cytokine production from immunocytes. Recent our studies have demonstrated that lentinan suppresses hepatic CYP1As expression in the both constitutive and inducible levels through the production of tumor necrosis factor-α and an increase in the DNA-binding activity of nuclear factor-κB. This paper discusses on the effective lentinan dosage and route of administration for suppression of CYP1As.
| Original language | English |
|---|---|
| Pages (from-to) | 407-409 |
| Number of pages | 3 |
| Journal | BioFactors |
| Volume | 21 |
| Issue number | 1-4 |
| DOIs | |
| Publication status | Published - Jan 1 2004 |
| Externally published | Yes |
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Keywords
- CYP1A subfamily
- Lentinan
- NF-κB
- TNF-α
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Clinical Biochemistry
Cite this
Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver. / Okamoto, Takashi; Kodoi, Rie; Nonaka, Yuji; Fukuda, Itsuko; Hashimoto, Takashi; Kanazawa, Kazuki; Mizuno, Masashi; Ashida, Hitoshi.
In: BioFactors, Vol. 21, No. 1-4, 01.01.2004, p. 407-409.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver
AU - Okamoto, Takashi
AU - Kodoi, Rie
AU - Nonaka, Yuji
AU - Fukuda, Itsuko
AU - Hashimoto, Takashi
AU - Kanazawa, Kazuki
AU - Mizuno, Masashi
AU - Ashida, Hitoshi
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Induction of xenobiotics metabolizing enzymes is related to the formation and chemoprevention of cancer. Since cytochrome P450s (CYPs) including CYP1A subfamily metabolize certain pro-carcinogens to their ultimate forms, down-regulation of CYP1As by food factors leads to the prevention of cancer. Mushroom polysaccharides, especially β-glucans such as lentinan from Lentinus edodes, possess the anti-tumor and immunomodulating activities through the cytokine production from immunocytes. Recent our studies have demonstrated that lentinan suppresses hepatic CYP1As expression in the both constitutive and inducible levels through the production of tumor necrosis factor-α and an increase in the DNA-binding activity of nuclear factor-κB. This paper discusses on the effective lentinan dosage and route of administration for suppression of CYP1As.
AB - Induction of xenobiotics metabolizing enzymes is related to the formation and chemoprevention of cancer. Since cytochrome P450s (CYPs) including CYP1A subfamily metabolize certain pro-carcinogens to their ultimate forms, down-regulation of CYP1As by food factors leads to the prevention of cancer. Mushroom polysaccharides, especially β-glucans such as lentinan from Lentinus edodes, possess the anti-tumor and immunomodulating activities through the cytokine production from immunocytes. Recent our studies have demonstrated that lentinan suppresses hepatic CYP1As expression in the both constitutive and inducible levels through the production of tumor necrosis factor-α and an increase in the DNA-binding activity of nuclear factor-κB. This paper discusses on the effective lentinan dosage and route of administration for suppression of CYP1As.
KW - CYP1A subfamily
KW - Lentinan
KW - NF-κB
KW - TNF-α
UR - http://www.scopus.com/inward/record.url?scp=16444363000&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16444363000&partnerID=8YFLogxK
U2 - 10.1002/biof.552210180
DO - 10.1002/biof.552210180
M3 - Article
C2 - 15630237
AN - SCOPUS:16444363000
VL - 21
SP - 407
EP - 409
JO - BioFactors
JF - BioFactors
SN - 0951-6433
IS - 1-4
ER -