Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver

Takashi Okamoto, Rie Kodoi, Yuji Nonaka, Itsuko Fukuda, Takashi Hashimoto, Kazuki Kanazawa, Masashi Mizuno, Hitoshi Ashida

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Induction of xenobiotics metabolizing enzymes is related to the formation and chemoprevention of cancer. Since cytochrome P450s (CYPs) including CYP1A subfamily metabolize certain pro-carcinogens to their ultimate forms, down-regulation of CYP1As by food factors leads to the prevention of cancer. Mushroom polysaccharides, especially β-glucans such as lentinan from Lentinus edodes, possess the anti-tumor and immunomodulating activities through the cytokine production from immunocytes. Recent our studies have demonstrated that lentinan suppresses hepatic CYP1As expression in the both constitutive and inducible levels through the production of tumor necrosis factor-α and an increase in the DNA-binding activity of nuclear factor-κB. This paper discusses on the effective lentinan dosage and route of administration for suppression of CYP1As.

Original languageEnglish
Pages (from-to)407-409
Number of pages3
JournalBioFactors
Volume21
Issue number1-4
DOIs
Publication statusPublished - Jan 1 2004
Externally publishedYes

Keywords

  • CYP1A subfamily
  • Lentinan
  • NF-κB
  • TNF-α

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

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    Okamoto, T., Kodoi, R., Nonaka, Y., Fukuda, I., Hashimoto, T., Kanazawa, K., Mizuno, M., & Ashida, H. (2004). Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver. BioFactors, 21(1-4), 407-409. https://doi.org/10.1002/biof.552210180