Leishmania amazonensis infection in nude mice

Masaki Terabe, Toshimitsu Hatabu, Hidemi Takahashi, Mamoru Ito, Takashi Onodera, Yoshitsugu Matsumoto

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Leishmania amazonensis is an intracellular protozoan parasite of macrophages. Cutaneous leishmaniasis in an immunocompetent host begins as papules or nodules followed by ulceration at the site of promastigote inoculation. In this study, the pathological changes of cutaneous leishmaniasis lesions in T cell deficient nude mice were examined. When infected with L. amazonensis promastigotes, nude mice developed non-ulcerative cutaneous nodules. By histological examination of cutaneous lesions, massive accumulation of vacuolated histiocytes containing amastigotes was observed in all the nude mice. Although infiltration of mononuclear and polymorphonuclear cells was seen in the lesions of immunocompetent mice, few such cells were observed in the lesions of nude mice. These results indicate the importance of T cells on the ulcer formation in cutaneous leishmaniasis.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalExperimental Animals
Volume48
Issue number2
DOIs
Publication statusPublished - Apr 1999

Keywords

  • Leishmania amazonensis
  • Nude mice
  • T cell

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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