Abstract
In contrast to higher vertebrates, orthopteran nymphs have remarkable regenerative capacity for regrowing complex morphological structures and organs. In this review, we summarize the molecular basis of tissue regeneration in the cricket Gryllus bimaculatus. In this species, the lost part of a leg can be regenerated epimorphically from blastema cells, a population of dedifferentiated proliferating cells. Blastema cell proliferation is regulated by JAK/STAT and Salvador/Warts/Hippo signaling pathways. The positional information for leg regrowth, which includes the recognition of amputated position and proper regeneration, is maintained by Dachsous/Fat signaling. The regrowth of lost leg segments is reconstructed through the expressions of genes in the hedgehog, wingless, decapentaplegic, and Egf signaling pathways and epigenetic modifiers E(z) and Utx. The insights obtained reveal the high level of conservation between insects and vertebrates, suggesting that Gryllus may be a suitable model for human regenerative medicine studies.
| Original language | English |
|---|---|
| Title of host publication | The Cricket as a Model Organism |
| Subtitle of host publication | Development, Regeneration, and Behavior |
| Publisher | Springer Japan |
| Pages | 31-48 |
| Number of pages | 18 |
| ISBN (Electronic) | 9784431564782 |
| ISBN (Print) | 9784431564768 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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Keywords
- Blastema
- Dachsous/Fat
- Histone H3K27me3
- JAK/STAT signaling
- Positional information
- Salvador/Warts/Hippo signaling
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Engineering(all)
Cite this
Leg formation and regeneration. / Bando, Tetsuya; Hamada, Yoshimasa; Noji, Sumihare.
The Cricket as a Model Organism: Development, Regeneration, and Behavior. Springer Japan, 2017. p. 31-48.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Leg formation and regeneration
AU - Bando, Tetsuya
AU - Hamada, Yoshimasa
AU - Noji, Sumihare
PY - 2017/1/1
Y1 - 2017/1/1
N2 - In contrast to higher vertebrates, orthopteran nymphs have remarkable regenerative capacity for regrowing complex morphological structures and organs. In this review, we summarize the molecular basis of tissue regeneration in the cricket Gryllus bimaculatus. In this species, the lost part of a leg can be regenerated epimorphically from blastema cells, a population of dedifferentiated proliferating cells. Blastema cell proliferation is regulated by JAK/STAT and Salvador/Warts/Hippo signaling pathways. The positional information for leg regrowth, which includes the recognition of amputated position and proper regeneration, is maintained by Dachsous/Fat signaling. The regrowth of lost leg segments is reconstructed through the expressions of genes in the hedgehog, wingless, decapentaplegic, and Egf signaling pathways and epigenetic modifiers E(z) and Utx. The insights obtained reveal the high level of conservation between insects and vertebrates, suggesting that Gryllus may be a suitable model for human regenerative medicine studies.
AB - In contrast to higher vertebrates, orthopteran nymphs have remarkable regenerative capacity for regrowing complex morphological structures and organs. In this review, we summarize the molecular basis of tissue regeneration in the cricket Gryllus bimaculatus. In this species, the lost part of a leg can be regenerated epimorphically from blastema cells, a population of dedifferentiated proliferating cells. Blastema cell proliferation is regulated by JAK/STAT and Salvador/Warts/Hippo signaling pathways. The positional information for leg regrowth, which includes the recognition of amputated position and proper regeneration, is maintained by Dachsous/Fat signaling. The regrowth of lost leg segments is reconstructed through the expressions of genes in the hedgehog, wingless, decapentaplegic, and Egf signaling pathways and epigenetic modifiers E(z) and Utx. The insights obtained reveal the high level of conservation between insects and vertebrates, suggesting that Gryllus may be a suitable model for human regenerative medicine studies.
KW - Blastema
KW - Dachsous/Fat
KW - Histone H3K27me3
KW - JAK/STAT signaling
KW - Positional information
KW - Salvador/Warts/Hippo signaling
UR - http://www.scopus.com/inward/record.url?scp=85042840739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042840739&partnerID=8YFLogxK
U2 - 10.1007/978-4-431-56478-2_3
DO - 10.1007/978-4-431-56478-2_3
M3 - Chapter
AN - SCOPUS:85042840739
SN - 9784431564768
SP - 31
EP - 48
BT - The Cricket as a Model Organism
PB - Springer Japan
ER -