Leg formation and regeneration

Tetsuya Bando, Yoshimasa Hamada, Sumihare Noji

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In contrast to higher vertebrates, orthopteran nymphs have remarkable regenerative capacity for regrowing complex morphological structures and organs. In this review, we summarize the molecular basis of tissue regeneration in the cricket Gryllus bimaculatus. In this species, the lost part of a leg can be regenerated epimorphically from blastema cells, a population of dedifferentiated proliferating cells. Blastema cell proliferation is regulated by JAK/STAT and Salvador/Warts/Hippo signaling pathways. The positional information for leg regrowth, which includes the recognition of amputated position and proper regeneration, is maintained by Dachsous/Fat signaling. The regrowth of lost leg segments is reconstructed through the expressions of genes in the hedgehog, wingless, decapentaplegic, and Egf signaling pathways and epigenetic modifiers E(z) and Utx. The insights obtained reveal the high level of conservation between insects and vertebrates, suggesting that Gryllus may be a suitable model for human regenerative medicine studies.

Original languageEnglish
Title of host publicationThe Cricket as a Model Organism
Subtitle of host publicationDevelopment, Regeneration, and Behavior
PublisherSpringer Japan
Pages31-48
Number of pages18
ISBN (Electronic)9784431564782
ISBN (Print)9784431564768
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Regeneration
Leg
legs
regrowth
Vertebrates
vertebrates
Gryllus
Gryllidae
Gryllus bimaculatus
Nymph
warts
Tissue regeneration
Warts
Regenerative Medicine
modifiers (genes)
Hedgehogs
Erinaceidae
Cell proliferation
Oils and fats
tissue repair

Keywords

  • Blastema
  • Dachsous/Fat
  • Histone H3K27me3
  • JAK/STAT signaling
  • Positional information
  • Salvador/Warts/Hippo signaling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)

Cite this

Bando, T., Hamada, Y., & Noji, S. (2017). Leg formation and regeneration. In The Cricket as a Model Organism: Development, Regeneration, and Behavior (pp. 31-48). Springer Japan. https://doi.org/10.1007/978-4-431-56478-2_3

Leg formation and regeneration. / Bando, Tetsuya; Hamada, Yoshimasa; Noji, Sumihare.

The Cricket as a Model Organism: Development, Regeneration, and Behavior. Springer Japan, 2017. p. 31-48.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bando, T, Hamada, Y & Noji, S 2017, Leg formation and regeneration. in The Cricket as a Model Organism: Development, Regeneration, and Behavior. Springer Japan, pp. 31-48. https://doi.org/10.1007/978-4-431-56478-2_3
Bando T, Hamada Y, Noji S. Leg formation and regeneration. In The Cricket as a Model Organism: Development, Regeneration, and Behavior. Springer Japan. 2017. p. 31-48 https://doi.org/10.1007/978-4-431-56478-2_3
Bando, Tetsuya ; Hamada, Yoshimasa ; Noji, Sumihare. / Leg formation and regeneration. The Cricket as a Model Organism: Development, Regeneration, and Behavior. Springer Japan, 2017. pp. 31-48
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