Layer-specific activation of sensory input and predictive feedback in the human primary somatosensory cortex

Yinghua Yu, Laurentius Huber, Jiajia Yang, David C. Jangraw, Daniel A. Handwerker, Peter J. Molfese, Gang Chen, Yoshimichi Ejima, Jinglong Wu, Peter A. Bandettini

Research output: Contribution to journalArticle

Abstract

When humans perceive a sensation, their brains integrate inputs from sensory receptors and process them based on their expectations. The mechanisms of this predictive coding in the human somatosensory system are not fully understood. We fill a basic gap in our understanding of the predictive processing of somatosensation by examining the layer-specific activity in sensory input and predictive feedback in the human primary somatosensory cortex (S1). We acquired submillimeter functional magnetic resonance imaging data at 7T (n = 10) during a task of perceived, predictable, and unpredictable touching sequences. We demonstrate that the sensory input from thalamic projects preferentially activates the middle layer, while the superficial and deep layers in S1 are more engaged for cortico-cortical predictive feedback input. These findings are pivotal to understanding the mechanisms of tactile prediction processing in the human somatosensory cortex.

Original languageEnglish
Article numbereaav9053
JournalScience Advances
Volume5
Issue number5
DOIs
Publication statusPublished - May 15 2019

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cortexes
activation
brain
magnetic resonance
coding
predictions

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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Yu, Y., Huber, L., Yang, J., Jangraw, D. C., Handwerker, D. A., Molfese, P. J., ... Bandettini, P. A. (2019). Layer-specific activation of sensory input and predictive feedback in the human primary somatosensory cortex. Science Advances, 5(5), [eaav9053]. https://doi.org/10.1126/sciadv.aav9053

Layer-specific activation of sensory input and predictive feedback in the human primary somatosensory cortex. / Yu, Yinghua; Huber, Laurentius; Yang, Jiajia; Jangraw, David C.; Handwerker, Daniel A.; Molfese, Peter J.; Chen, Gang; Ejima, Yoshimichi; Wu, Jinglong; Bandettini, Peter A.

In: Science Advances, Vol. 5, No. 5, eaav9053, 15.05.2019.

Research output: Contribution to journalArticle

Yu, Y, Huber, L, Yang, J, Jangraw, DC, Handwerker, DA, Molfese, PJ, Chen, G, Ejima, Y, Wu, J & Bandettini, PA 2019, 'Layer-specific activation of sensory input and predictive feedback in the human primary somatosensory cortex', Science Advances, vol. 5, no. 5, eaav9053. https://doi.org/10.1126/sciadv.aav9053
Yu, Yinghua ; Huber, Laurentius ; Yang, Jiajia ; Jangraw, David C. ; Handwerker, Daniel A. ; Molfese, Peter J. ; Chen, Gang ; Ejima, Yoshimichi ; Wu, Jinglong ; Bandettini, Peter A. / Layer-specific activation of sensory input and predictive feedback in the human primary somatosensory cortex. In: Science Advances. 2019 ; Vol. 5, No. 5.
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