Lateralized interictal epileptiform discharges during rapid eye movement sleep correlate with epileptogenic hemisphere in children with intractable epilepsy secondary to tuberous sclerosis complex

Ayako Ochi, Ryan Hung, Shelly Weiss, Elysa Widjaja, Tonia To, Yoshihiro Nawa, Taiki Shima, Cristina Go, Tomoyuki Akiyama, Elizabeth Donner, James Drake, James T. Rutka, O. Carter Snead, Hiroshi Otsubo

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Abstract

Purpose: We assessed lateralization of interictal epileptiform discharges (IEDs) in children with intractable epilepsy secondary to tuberous sclerosis complexes (TSCs) during rapid eye movement sleep (R), compared with non-rapid eye movement sleep (NR) and wakefulness (W), to determine epileptogenicity of R-IEDs. Methods: We retrospectively studied 23 children with TSC, who underwent prolonged scalp video-electroencephalography (EEG) and magnetic resonance imaging (MRI). We determined the lateralization of ictal EEG, clinical semiology, and the largest tuber on MRI. We analyzed a minimum of 100 IEDs during R, NR, and W to classify right/left/generalized spikes to compare the lateralization with ictal EEG, clinical semiology, and MRI. Key Findings: R-IEDs were lateralized in 22 patients (96%), W-IEDs in 19 (83%), and NR-IEDs in 16 (70%). Ictal EEGs were lateralized in 15 patients (65%) and clinical semiology in 5 (22%). Ictal EEG lateralization was concordant to R-IEDs in 14 patients (93%), W-IEDs in 11 (73%), and NR-IEDs in 10 (67%). The lateralization of clinical semiology was concordant with R-IEDs in 4 (80%), W-IEDs in 3 (60%), and NR-IEDs in 2 (40%). MRI lateralization of the largest tuber was concordant with R-IEDs in 16 (70%), W-IEDs in 12 (52%), and NR-IEDs in 11 (48%). Thirteen patients (57%) underwent resective surgery, the hemisphere of which was concordant with R-IEDs in 13 (100%), W-IEDs in 8 (62%), and NR-IEDs in 8 (62%). Nine (69%) of them achieved good seizure control after surgery. Significance: R provoked the most lateralized IEDs compared to NR and W in children with TSC. Lateralization of R-IEDs corresponded with the hemisphere of ictal EEG and largest tuber, and can be used to identify surgical candidacy in TSC children with intractable epilepsy.

Original languageEnglish
Pages (from-to)1986-1994
Number of pages9
JournalEpilepsia
Volume52
Issue number11
DOIs
Publication statusPublished - Nov 2011
Externally publishedYes

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Tuberous Sclerosis
REM Sleep
Electroencephalography
Sleep
Stroke
Magnetic Resonance Imaging
Wakefulness
Eye Movements
Scalp
Drug Resistant Epilepsy
Seizures

Keywords

  • Children
  • Desynchronization
  • Lateralized epileptogenic hemisphere
  • Resective surgery
  • Thalamocortical interaction

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Lateralized interictal epileptiform discharges during rapid eye movement sleep correlate with epileptogenic hemisphere in children with intractable epilepsy secondary to tuberous sclerosis complex. / Ochi, Ayako; Hung, Ryan; Weiss, Shelly; Widjaja, Elysa; To, Tonia; Nawa, Yoshihiro; Shima, Taiki; Go, Cristina; Akiyama, Tomoyuki; Donner, Elizabeth; Drake, James; Rutka, James T.; Snead, O. Carter; Otsubo, Hiroshi.

In: Epilepsia, Vol. 52, No. 11, 11.2011, p. 1986-1994.

Research output: Contribution to journalArticle

Ochi, Ayako ; Hung, Ryan ; Weiss, Shelly ; Widjaja, Elysa ; To, Tonia ; Nawa, Yoshihiro ; Shima, Taiki ; Go, Cristina ; Akiyama, Tomoyuki ; Donner, Elizabeth ; Drake, James ; Rutka, James T. ; Snead, O. Carter ; Otsubo, Hiroshi. / Lateralized interictal epileptiform discharges during rapid eye movement sleep correlate with epileptogenic hemisphere in children with intractable epilepsy secondary to tuberous sclerosis complex. In: Epilepsia. 2011 ; Vol. 52, No. 11. pp. 1986-1994.
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abstract = "Purpose: We assessed lateralization of interictal epileptiform discharges (IEDs) in children with intractable epilepsy secondary to tuberous sclerosis complexes (TSCs) during rapid eye movement sleep (R), compared with non-rapid eye movement sleep (NR) and wakefulness (W), to determine epileptogenicity of R-IEDs. Methods: We retrospectively studied 23 children with TSC, who underwent prolonged scalp video-electroencephalography (EEG) and magnetic resonance imaging (MRI). We determined the lateralization of ictal EEG, clinical semiology, and the largest tuber on MRI. We analyzed a minimum of 100 IEDs during R, NR, and W to classify right/left/generalized spikes to compare the lateralization with ictal EEG, clinical semiology, and MRI. Key Findings: R-IEDs were lateralized in 22 patients (96{\%}), W-IEDs in 19 (83{\%}), and NR-IEDs in 16 (70{\%}). Ictal EEGs were lateralized in 15 patients (65{\%}) and clinical semiology in 5 (22{\%}). Ictal EEG lateralization was concordant to R-IEDs in 14 patients (93{\%}), W-IEDs in 11 (73{\%}), and NR-IEDs in 10 (67{\%}). The lateralization of clinical semiology was concordant with R-IEDs in 4 (80{\%}), W-IEDs in 3 (60{\%}), and NR-IEDs in 2 (40{\%}). MRI lateralization of the largest tuber was concordant with R-IEDs in 16 (70{\%}), W-IEDs in 12 (52{\%}), and NR-IEDs in 11 (48{\%}). Thirteen patients (57{\%}) underwent resective surgery, the hemisphere of which was concordant with R-IEDs in 13 (100{\%}), W-IEDs in 8 (62{\%}), and NR-IEDs in 8 (62{\%}). Nine (69{\%}) of them achieved good seizure control after surgery. Significance: R provoked the most lateralized IEDs compared to NR and W in children with TSC. Lateralization of R-IEDs corresponded with the hemisphere of ictal EEG and largest tuber, and can be used to identify surgical candidacy in TSC children with intractable epilepsy.",
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T1 - Lateralized interictal epileptiform discharges during rapid eye movement sleep correlate with epileptogenic hemisphere in children with intractable epilepsy secondary to tuberous sclerosis complex

AU - Ochi, Ayako

AU - Hung, Ryan

AU - Weiss, Shelly

AU - Widjaja, Elysa

AU - To, Tonia

AU - Nawa, Yoshihiro

AU - Shima, Taiki

AU - Go, Cristina

AU - Akiyama, Tomoyuki

AU - Donner, Elizabeth

AU - Drake, James

AU - Rutka, James T.

AU - Snead, O. Carter

AU - Otsubo, Hiroshi

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N2 - Purpose: We assessed lateralization of interictal epileptiform discharges (IEDs) in children with intractable epilepsy secondary to tuberous sclerosis complexes (TSCs) during rapid eye movement sleep (R), compared with non-rapid eye movement sleep (NR) and wakefulness (W), to determine epileptogenicity of R-IEDs. Methods: We retrospectively studied 23 children with TSC, who underwent prolonged scalp video-electroencephalography (EEG) and magnetic resonance imaging (MRI). We determined the lateralization of ictal EEG, clinical semiology, and the largest tuber on MRI. We analyzed a minimum of 100 IEDs during R, NR, and W to classify right/left/generalized spikes to compare the lateralization with ictal EEG, clinical semiology, and MRI. Key Findings: R-IEDs were lateralized in 22 patients (96%), W-IEDs in 19 (83%), and NR-IEDs in 16 (70%). Ictal EEGs were lateralized in 15 patients (65%) and clinical semiology in 5 (22%). Ictal EEG lateralization was concordant to R-IEDs in 14 patients (93%), W-IEDs in 11 (73%), and NR-IEDs in 10 (67%). The lateralization of clinical semiology was concordant with R-IEDs in 4 (80%), W-IEDs in 3 (60%), and NR-IEDs in 2 (40%). MRI lateralization of the largest tuber was concordant with R-IEDs in 16 (70%), W-IEDs in 12 (52%), and NR-IEDs in 11 (48%). Thirteen patients (57%) underwent resective surgery, the hemisphere of which was concordant with R-IEDs in 13 (100%), W-IEDs in 8 (62%), and NR-IEDs in 8 (62%). Nine (69%) of them achieved good seizure control after surgery. Significance: R provoked the most lateralized IEDs compared to NR and W in children with TSC. Lateralization of R-IEDs corresponded with the hemisphere of ictal EEG and largest tuber, and can be used to identify surgical candidacy in TSC children with intractable epilepsy.

AB - Purpose: We assessed lateralization of interictal epileptiform discharges (IEDs) in children with intractable epilepsy secondary to tuberous sclerosis complexes (TSCs) during rapid eye movement sleep (R), compared with non-rapid eye movement sleep (NR) and wakefulness (W), to determine epileptogenicity of R-IEDs. Methods: We retrospectively studied 23 children with TSC, who underwent prolonged scalp video-electroencephalography (EEG) and magnetic resonance imaging (MRI). We determined the lateralization of ictal EEG, clinical semiology, and the largest tuber on MRI. We analyzed a minimum of 100 IEDs during R, NR, and W to classify right/left/generalized spikes to compare the lateralization with ictal EEG, clinical semiology, and MRI. Key Findings: R-IEDs were lateralized in 22 patients (96%), W-IEDs in 19 (83%), and NR-IEDs in 16 (70%). Ictal EEGs were lateralized in 15 patients (65%) and clinical semiology in 5 (22%). Ictal EEG lateralization was concordant to R-IEDs in 14 patients (93%), W-IEDs in 11 (73%), and NR-IEDs in 10 (67%). The lateralization of clinical semiology was concordant with R-IEDs in 4 (80%), W-IEDs in 3 (60%), and NR-IEDs in 2 (40%). MRI lateralization of the largest tuber was concordant with R-IEDs in 16 (70%), W-IEDs in 12 (52%), and NR-IEDs in 11 (48%). Thirteen patients (57%) underwent resective surgery, the hemisphere of which was concordant with R-IEDs in 13 (100%), W-IEDs in 8 (62%), and NR-IEDs in 8 (62%). Nine (69%) of them achieved good seizure control after surgery. Significance: R provoked the most lateralized IEDs compared to NR and W in children with TSC. Lateralization of R-IEDs corresponded with the hemisphere of ictal EEG and largest tuber, and can be used to identify surgical candidacy in TSC children with intractable epilepsy.

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KW - Desynchronization

KW - Lateralized epileptogenic hemisphere

KW - Resective surgery

KW - Thalamocortical interaction

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