Abstract
A 71-year-old man underwent laparoscopic partial gastrectomy for a gastric submucosal tumor in 1997; subsequently, he underwent follow-up without therapy. In December 2008, he noticed a mass at the umbilical wound. Computed tomography and physical examination of the umbilical mass indicated suspected recurrence of the gastric submucosal tumor at the port site. Because the lesion was locally confined, surgery was performed, including resection of the greater omentum; peritoneum; rectus abdominis; and the navel, including the skin. Histologic analysis of the tumor yielded positive results for c-kit, thereby indicating a gastrointestinal stromal tumor (GIST). Mutation analysis of c-kit and platelet-derived growth factor receptor α (PDGFRα) revealed an acquired mutation in exon 18 of PDGFRα in the recurrent tumor. To date, only 4 cases of port-site recurrence after laparoscopic resection of GIST have been reported. This is the first study to report an acquired PDGFRα mutation in port-site recurrence after laparoscopic resection of a GIST.
| Original language | English |
|---|---|
| Journal | Surgical Laparoscopy, Endoscopy and Percutaneous Techniques |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2012 |
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Keywords
- gastrointestinal stromal tumor
- laparoscopic surgery
- PDGFRα mutation
- port-site recurrence
ASJC Scopus subject areas
- Surgery
Cite this
Late umbilical port-site recurrence of a gastrointestinal stromal tumor with an acquired PDGFRα mutation after laparoscopic resection : Report of a case. / Furukawa, Masashi; Izumi, Sadanobu; Asano, Hiroaki; Tokumo, Masaki; Mano, Shohey; Shiota, Kunihiko.
In: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques, Vol. 22, No. 2, 04.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Late umbilical port-site recurrence of a gastrointestinal stromal tumor with an acquired PDGFRα mutation after laparoscopic resection
T2 - Report of a case
AU - Furukawa, Masashi
AU - Izumi, Sadanobu
AU - Asano, Hiroaki
AU - Tokumo, Masaki
AU - Mano, Shohey
AU - Shiota, Kunihiko
PY - 2012/4
Y1 - 2012/4
N2 - A 71-year-old man underwent laparoscopic partial gastrectomy for a gastric submucosal tumor in 1997; subsequently, he underwent follow-up without therapy. In December 2008, he noticed a mass at the umbilical wound. Computed tomography and physical examination of the umbilical mass indicated suspected recurrence of the gastric submucosal tumor at the port site. Because the lesion was locally confined, surgery was performed, including resection of the greater omentum; peritoneum; rectus abdominis; and the navel, including the skin. Histologic analysis of the tumor yielded positive results for c-kit, thereby indicating a gastrointestinal stromal tumor (GIST). Mutation analysis of c-kit and platelet-derived growth factor receptor α (PDGFRα) revealed an acquired mutation in exon 18 of PDGFRα in the recurrent tumor. To date, only 4 cases of port-site recurrence after laparoscopic resection of GIST have been reported. This is the first study to report an acquired PDGFRα mutation in port-site recurrence after laparoscopic resection of a GIST.
AB - A 71-year-old man underwent laparoscopic partial gastrectomy for a gastric submucosal tumor in 1997; subsequently, he underwent follow-up without therapy. In December 2008, he noticed a mass at the umbilical wound. Computed tomography and physical examination of the umbilical mass indicated suspected recurrence of the gastric submucosal tumor at the port site. Because the lesion was locally confined, surgery was performed, including resection of the greater omentum; peritoneum; rectus abdominis; and the navel, including the skin. Histologic analysis of the tumor yielded positive results for c-kit, thereby indicating a gastrointestinal stromal tumor (GIST). Mutation analysis of c-kit and platelet-derived growth factor receptor α (PDGFRα) revealed an acquired mutation in exon 18 of PDGFRα in the recurrent tumor. To date, only 4 cases of port-site recurrence after laparoscopic resection of GIST have been reported. This is the first study to report an acquired PDGFRα mutation in port-site recurrence after laparoscopic resection of a GIST.
KW - gastrointestinal stromal tumor
KW - laparoscopic surgery
KW - PDGFRα mutation
KW - port-site recurrence
UR - http://www.scopus.com/inward/record.url?scp=84859636022&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859636022&partnerID=8YFLogxK
U2 - 10.1097/SLE.0b013e3182479e1f
DO - 10.1097/SLE.0b013e3182479e1f
M3 - Article
C2 - 22487635
AN - SCOPUS:84859636022
VL - 22
JO - Surgical Laparoscopy, Endoscopy and Percutaneous Techniques
JF - Surgical Laparoscopy, Endoscopy and Percutaneous Techniques
SN - 1530-4515
IS - 2
ER -