Large waist circumference is a risk factor for reflux esophagitis in Japanese males

Hisae Yasuhara, Yasuhiro Miyake, Tatsuya Toyokawa, Kazuyuki Matsumoto, Masahiro Takahara, Takayuki Imada, Satoru Yagi, Hirokazu Miyatake, Morihito Nakatsu, Masaharu Ando, Mamoru Hirohata

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background/Aims: The prevalence of reflux esophagitis, which might lead to development of Barrett's esophagus and esophageal adenocarcinoma, has been increasing. The aim of this study was to assess risk factors for reflux esophagitis. Methods: We conducted a cross-sectional study of 1,495 Japanese subjects undergoing health checkups (822 males and 673 females; median age 50 years) at a tertiary care center. Results: One hundred and twenty-seven subjects (8%) had reflux esophagitis and hiatal hernia was observed in 292 subjects (20%). Reflux esophagitis (13 vs. 3%) and hiatal hernia (28 vs. 9%) were more frequent in males than females. Significant differences in clinical backgrounds were observed between females and males. Multivariate logistic regression analyses revealed that hiatal hernia (OR 6.63, 95% CI 2.47-17.8; p = 0.0002) was associated with reflux esophagitis in females. In males, age (per 1-year increment: OR 0.96, 95% CI 0.94-0.99; p = 0.007), hiatal hernia (OR 3.16, 95% CI 2.05-4.87; p < 0.0001) and waist circumference (per 1-cm increase: OR 1.09, 95% CI 1.02-1.15; p = 0.006) were associated with reflux esophagitis. Conclusions: Abdominal obesity may be an important risk factor for reflux esophagitis in males compared with females.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalDigestion
Volume81
Issue number3
DOIs
Publication statusPublished - Feb 2010
Externally publishedYes

Fingerprint

Peptic Esophagitis
Waist Circumference
Hiatal Hernia
Barrett Esophagus
Abdominal Obesity
Tertiary Care Centers
Adenocarcinoma
Cross-Sectional Studies
Logistic Models
Regression Analysis
Health

Keywords

  • Abdominal obesity
  • Hiatal hernia
  • Reflux esophagitis
  • Risk factor
  • Waist circumference

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Yasuhara, H., Miyake, Y., Toyokawa, T., Matsumoto, K., Takahara, M., Imada, T., ... Hirohata, M. (2010). Large waist circumference is a risk factor for reflux esophagitis in Japanese males. Digestion, 81(3), 181-187. https://doi.org/10.1159/000235919

Large waist circumference is a risk factor for reflux esophagitis in Japanese males. / Yasuhara, Hisae; Miyake, Yasuhiro; Toyokawa, Tatsuya; Matsumoto, Kazuyuki; Takahara, Masahiro; Imada, Takayuki; Yagi, Satoru; Miyatake, Hirokazu; Nakatsu, Morihito; Ando, Masaharu; Hirohata, Mamoru.

In: Digestion, Vol. 81, No. 3, 02.2010, p. 181-187.

Research output: Contribution to journalArticle

Yasuhara, H, Miyake, Y, Toyokawa, T, Matsumoto, K, Takahara, M, Imada, T, Yagi, S, Miyatake, H, Nakatsu, M, Ando, M & Hirohata, M 2010, 'Large waist circumference is a risk factor for reflux esophagitis in Japanese males', Digestion, vol. 81, no. 3, pp. 181-187. https://doi.org/10.1159/000235919
Yasuhara, Hisae ; Miyake, Yasuhiro ; Toyokawa, Tatsuya ; Matsumoto, Kazuyuki ; Takahara, Masahiro ; Imada, Takayuki ; Yagi, Satoru ; Miyatake, Hirokazu ; Nakatsu, Morihito ; Ando, Masaharu ; Hirohata, Mamoru. / Large waist circumference is a risk factor for reflux esophagitis in Japanese males. In: Digestion. 2010 ; Vol. 81, No. 3. pp. 181-187.
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AU - Takahara, Masahiro

AU - Imada, Takayuki

AU - Yagi, Satoru

AU - Miyatake, Hirokazu

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AU - Ando, Masaharu

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