Laparoscopic Hepatectomy for the Patient with Hemophilia A with High Titer Factor VIII Inhibitor

Tatsuo Matsuda, Yuzo Umeda, Kazuhiro Yoshida, Tadakazu Matsuda, Masatoshi Uno, Masaya Abe, Noboru Asada, Yoshinobu Maeda, Takahito Yagi, Toshiyoshi Fujiwara

Research output: Contribution to journalArticlepeer-review

Abstract

We present the first case of laparoscopic left lateral segmentectomy for hepatocellular carcinoma (HCC) in a patient with hemophilia A, acquired hepatitis C, and high-titer factor VIII inhibitor, which was confirmed by preoperative diagnosis. He underwent laparoscopic left lateral segmentectomy with the administration of recombinant activated factor VII. Surgery could be performed with reduced intraoperative hemorrhage. He experienced postoperative intra-abdominal wall hemorrhage, which was successfully managed with red cell concentrates transfusion and administration of recombinant activated factor VII. Laparoscopic hepatectomy can be applied for hemophilia patients with high titer inhibitors.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalActa medica Okayama
Volume75
Issue number2
Publication statusPublished - 2021

Keywords

  • hemophilia A
  • hepatectomy
  • hepatocellular carcinoma
  • inhibitor
  • laparoscopy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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