Laparoscopic features of primary biliary cirrhosis in AMA-positive and AMA-negative patients

S. Fujioka, K. Yamamoto, R. Okamoto, M. Miyake, K. Ujike, N. Shimada, R. Terada, Y. Miyake, H. Nakajima, C. Y. Piao, Yoshiaki Iwasaki, M. Tanimizu, T. Tsuji

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background and study aims: Antimitochondrial antibody (AMA)-negative primary biliary cirrhosis (PBC) has been difficult to diagnose. Laparoscopic features of AMA-negative PBC were evaluated in comparison with those of AMA-positive PBC and autoimmune hepatitis. Patients and methods: 71 patients who fulfilled the diagnostic criteria for PBC were enrolled in the study; 48 were AMA-positive and 23 were AMA-negative. As a disease control, 46 autoimmune hepatitis patients were included. Both the frequency and specificity of each laparoscopic finding were evaluated. A laparoscopic scoring system was introduced, which used, common and uncommon laparoscopic findings, and was evaluated for the diagnosis of AMA-negative PBC. Results: The characteristic laparoscopic findings for AMA-positive PBC were yellowish-white marking (92%), dark-brown discoloration (73%), gentle undulation (67%), reddish patch (38%), and yellowish-white nodules (32%). On the other hand, laparoscopic findings such as trench-like depression, reddish markings, and wide and small depressions were uncommon in PBC compared with autoimmune hepatitis. The frequencies of characteristic and uncommon laparoscopic findings did not differ statistically between AMA-positive and AMA-negative PBC, but were different between AMA-positive or AMA-negative PBC and autoimmune hepatitis. Scores based on common and uncommon laparoscopic findings were 5.5 ± 1.5 (mean ± SD) in AMA-positive PBC, 5.6 ± 2.0 in AMA-negative PBC, and -0.30 ± 0.5 in autoimmune hepatitis. Conclusion: The laparoscopic findings in AMA-negative PBC did not differ from those of AMA-positive PBC. A laparoscopic scoring system may be helpful in the diagnosis of AMA-negative PBC.

Original languageEnglish
Pages (from-to)318-321
Number of pages4
JournalEndoscopy
Volume34
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint

Biliary Liver Cirrhosis
Antibodies
Autoimmune Hepatitis

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Fujioka, S., Yamamoto, K., Okamoto, R., Miyake, M., Ujike, K., Shimada, N., ... Tsuji, T. (2002). Laparoscopic features of primary biliary cirrhosis in AMA-positive and AMA-negative patients. Endoscopy, 34(4), 318-321. https://doi.org/10.1055/s-2002-23642

Laparoscopic features of primary biliary cirrhosis in AMA-positive and AMA-negative patients. / Fujioka, S.; Yamamoto, K.; Okamoto, R.; Miyake, M.; Ujike, K.; Shimada, N.; Terada, R.; Miyake, Y.; Nakajima, H.; Piao, C. Y.; Iwasaki, Yoshiaki; Tanimizu, M.; Tsuji, T.

In: Endoscopy, Vol. 34, No. 4, 2002, p. 318-321.

Research output: Contribution to journalArticle

Fujioka, S, Yamamoto, K, Okamoto, R, Miyake, M, Ujike, K, Shimada, N, Terada, R, Miyake, Y, Nakajima, H, Piao, CY, Iwasaki, Y, Tanimizu, M & Tsuji, T 2002, 'Laparoscopic features of primary biliary cirrhosis in AMA-positive and AMA-negative patients', Endoscopy, vol. 34, no. 4, pp. 318-321. https://doi.org/10.1055/s-2002-23642
Fujioka S, Yamamoto K, Okamoto R, Miyake M, Ujike K, Shimada N et al. Laparoscopic features of primary biliary cirrhosis in AMA-positive and AMA-negative patients. Endoscopy. 2002;34(4):318-321. https://doi.org/10.1055/s-2002-23642
Fujioka, S. ; Yamamoto, K. ; Okamoto, R. ; Miyake, M. ; Ujike, K. ; Shimada, N. ; Terada, R. ; Miyake, Y. ; Nakajima, H. ; Piao, C. Y. ; Iwasaki, Yoshiaki ; Tanimizu, M. ; Tsuji, T. / Laparoscopic features of primary biliary cirrhosis in AMA-positive and AMA-negative patients. In: Endoscopy. 2002 ; Vol. 34, No. 4. pp. 318-321.
@article{48165726cb5a4df4989ad9a99c2f10c8,
title = "Laparoscopic features of primary biliary cirrhosis in AMA-positive and AMA-negative patients",
abstract = "Background and study aims: Antimitochondrial antibody (AMA)-negative primary biliary cirrhosis (PBC) has been difficult to diagnose. Laparoscopic features of AMA-negative PBC were evaluated in comparison with those of AMA-positive PBC and autoimmune hepatitis. Patients and methods: 71 patients who fulfilled the diagnostic criteria for PBC were enrolled in the study; 48 were AMA-positive and 23 were AMA-negative. As a disease control, 46 autoimmune hepatitis patients were included. Both the frequency and specificity of each laparoscopic finding were evaluated. A laparoscopic scoring system was introduced, which used, common and uncommon laparoscopic findings, and was evaluated for the diagnosis of AMA-negative PBC. Results: The characteristic laparoscopic findings for AMA-positive PBC were yellowish-white marking (92{\%}), dark-brown discoloration (73{\%}), gentle undulation (67{\%}), reddish patch (38{\%}), and yellowish-white nodules (32{\%}). On the other hand, laparoscopic findings such as trench-like depression, reddish markings, and wide and small depressions were uncommon in PBC compared with autoimmune hepatitis. The frequencies of characteristic and uncommon laparoscopic findings did not differ statistically between AMA-positive and AMA-negative PBC, but were different between AMA-positive or AMA-negative PBC and autoimmune hepatitis. Scores based on common and uncommon laparoscopic findings were 5.5 ± 1.5 (mean ± SD) in AMA-positive PBC, 5.6 ± 2.0 in AMA-negative PBC, and -0.30 ± 0.5 in autoimmune hepatitis. Conclusion: The laparoscopic findings in AMA-negative PBC did not differ from those of AMA-positive PBC. A laparoscopic scoring system may be helpful in the diagnosis of AMA-negative PBC.",
author = "S. Fujioka and K. Yamamoto and R. Okamoto and M. Miyake and K. Ujike and N. Shimada and R. Terada and Y. Miyake and H. Nakajima and Piao, {C. Y.} and Yoshiaki Iwasaki and M. Tanimizu and T. Tsuji",
year = "2002",
doi = "10.1055/s-2002-23642",
language = "English",
volume = "34",
pages = "318--321",
journal = "Endoscopy",
issn = "0013-726X",
publisher = "Georg Thieme Verlag",
number = "4",

}

TY - JOUR

T1 - Laparoscopic features of primary biliary cirrhosis in AMA-positive and AMA-negative patients

AU - Fujioka, S.

AU - Yamamoto, K.

AU - Okamoto, R.

AU - Miyake, M.

AU - Ujike, K.

AU - Shimada, N.

AU - Terada, R.

AU - Miyake, Y.

AU - Nakajima, H.

AU - Piao, C. Y.

AU - Iwasaki, Yoshiaki

AU - Tanimizu, M.

AU - Tsuji, T.

PY - 2002

Y1 - 2002

N2 - Background and study aims: Antimitochondrial antibody (AMA)-negative primary biliary cirrhosis (PBC) has been difficult to diagnose. Laparoscopic features of AMA-negative PBC were evaluated in comparison with those of AMA-positive PBC and autoimmune hepatitis. Patients and methods: 71 patients who fulfilled the diagnostic criteria for PBC were enrolled in the study; 48 were AMA-positive and 23 were AMA-negative. As a disease control, 46 autoimmune hepatitis patients were included. Both the frequency and specificity of each laparoscopic finding were evaluated. A laparoscopic scoring system was introduced, which used, common and uncommon laparoscopic findings, and was evaluated for the diagnosis of AMA-negative PBC. Results: The characteristic laparoscopic findings for AMA-positive PBC were yellowish-white marking (92%), dark-brown discoloration (73%), gentle undulation (67%), reddish patch (38%), and yellowish-white nodules (32%). On the other hand, laparoscopic findings such as trench-like depression, reddish markings, and wide and small depressions were uncommon in PBC compared with autoimmune hepatitis. The frequencies of characteristic and uncommon laparoscopic findings did not differ statistically between AMA-positive and AMA-negative PBC, but were different between AMA-positive or AMA-negative PBC and autoimmune hepatitis. Scores based on common and uncommon laparoscopic findings were 5.5 ± 1.5 (mean ± SD) in AMA-positive PBC, 5.6 ± 2.0 in AMA-negative PBC, and -0.30 ± 0.5 in autoimmune hepatitis. Conclusion: The laparoscopic findings in AMA-negative PBC did not differ from those of AMA-positive PBC. A laparoscopic scoring system may be helpful in the diagnosis of AMA-negative PBC.

AB - Background and study aims: Antimitochondrial antibody (AMA)-negative primary biliary cirrhosis (PBC) has been difficult to diagnose. Laparoscopic features of AMA-negative PBC were evaluated in comparison with those of AMA-positive PBC and autoimmune hepatitis. Patients and methods: 71 patients who fulfilled the diagnostic criteria for PBC were enrolled in the study; 48 were AMA-positive and 23 were AMA-negative. As a disease control, 46 autoimmune hepatitis patients were included. Both the frequency and specificity of each laparoscopic finding were evaluated. A laparoscopic scoring system was introduced, which used, common and uncommon laparoscopic findings, and was evaluated for the diagnosis of AMA-negative PBC. Results: The characteristic laparoscopic findings for AMA-positive PBC were yellowish-white marking (92%), dark-brown discoloration (73%), gentle undulation (67%), reddish patch (38%), and yellowish-white nodules (32%). On the other hand, laparoscopic findings such as trench-like depression, reddish markings, and wide and small depressions were uncommon in PBC compared with autoimmune hepatitis. The frequencies of characteristic and uncommon laparoscopic findings did not differ statistically between AMA-positive and AMA-negative PBC, but were different between AMA-positive or AMA-negative PBC and autoimmune hepatitis. Scores based on common and uncommon laparoscopic findings were 5.5 ± 1.5 (mean ± SD) in AMA-positive PBC, 5.6 ± 2.0 in AMA-negative PBC, and -0.30 ± 0.5 in autoimmune hepatitis. Conclusion: The laparoscopic findings in AMA-negative PBC did not differ from those of AMA-positive PBC. A laparoscopic scoring system may be helpful in the diagnosis of AMA-negative PBC.

UR - http://www.scopus.com/inward/record.url?scp=0036208737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036208737&partnerID=8YFLogxK

U2 - 10.1055/s-2002-23642

DO - 10.1055/s-2002-23642

M3 - Article

VL - 34

SP - 318

EP - 321

JO - Endoscopy

JF - Endoscopy

SN - 0013-726X

IS - 4

ER -