Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma

Current Understanding and Differential Diagnosis

Hirokazu Nakamine, Mitsunori Yamakawa, Tadashi Yoshino, Takaya Fukumoto, Yasunori Enomoto, Itaru Matsumura

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Langerhans cell (LC) histiocytosis (LCH) and LC sarcoma (LCS) are proliferative processes consisting of cells having morphologic and phenotypic features of Langerhans cells (LCs), although the latter may have lost some of these features. Because neoplastic nature of LCH as well as LCS is more likely by recent studies, a category of LC hyperplasia can be better characterized. LCH and LCS are rarely seen in daily pathology practice, but it is important to accurately characterize these lesions. For this purpose, an outline covering proliferations of LC and related cells was constructed. The scheme of this outline is based especially on evaluating borderline lesions, neoplastic trans-differentiation, and degree of similarity with the normal counter-parts. In addition, the organization and update of the current classification scheme for histiocytic and dendritic-cell proliferations is presented.

Original languageEnglish
Pages (from-to)109-118
Number of pages10
JournalJournal of clinical and experimental hematopathology : JCEH
Volume56
Issue number2
Publication statusPublished - 2016

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Langerhans Cell Sarcoma
Langerhans Cell Histiocytosis
Langerhans Cells
Histiocytosis
Differential Diagnosis
Sarcoma
Dendritic Cells
Hyperplasia
Cell Proliferation
Pathology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma : Current Understanding and Differential Diagnosis. / Nakamine, Hirokazu; Yamakawa, Mitsunori; Yoshino, Tadashi; Fukumoto, Takaya; Enomoto, Yasunori; Matsumura, Itaru.

In: Journal of clinical and experimental hematopathology : JCEH, Vol. 56, No. 2, 2016, p. 109-118.

Research output: Contribution to journalReview article

Nakamine, Hirokazu ; Yamakawa, Mitsunori ; Yoshino, Tadashi ; Fukumoto, Takaya ; Enomoto, Yasunori ; Matsumura, Itaru. / Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma : Current Understanding and Differential Diagnosis. In: Journal of clinical and experimental hematopathology : JCEH. 2016 ; Vol. 56, No. 2. pp. 109-118.
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