Laminar Module Cascade from Layer 5 to 6 Implementing Cue-to-Target Conversion for Object Memory Retrieval in the Primate Temporal Cortex

Kenji W. Koyano, Masaki Takeda, Teppei Matsui, Toshiyuki Hirabayashi, Yohei Ohashi, Yasushi Miyashita

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The cerebral cortex computes through the canonical microcircuit that connects six stacked layers; however, how cortical processing streams operate in vivo, particularly in the higher association cortex, remains elusive. By developing a novel MRI-assisted procedure that reliably localizes recorded single neurons at resolution of six individual layers in monkey temporal cortex, we show that transformation of representations from a cued object to a to-be-recalled object occurs at the infragranular layer in a visual cued-recall task. This cue-to-target conversion started in layer 5 and was followed by layer 6. Finally, a subset of layer 6 neurons exclusively encoding the sought target became phase-locked to surrounding field potentials at theta frequency, suggesting that this coordinated cell assembly implements cortical long-distance outputs of the recalled target. Thus, this study proposes a link from local computation spanning laminar modules of the temporal cortex to the brain-wide network for memory retrieval in primates.

Original languageEnglish
Pages (from-to)518-529
Number of pages12
JournalNeuron
Volume92
Issue number2
DOIs
Publication statusPublished - Oct 19 2016
Externally publishedYes

Keywords

  • cortical layer
  • laminar localization
  • memory retrieval
  • microcircuit
  • monkey
  • MRI
  • temporal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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