Abstract
The cerebral cortex computes through the canonical microcircuit that connects six stacked layers; however, how cortical processing streams operate in vivo, particularly in the higher association cortex, remains elusive. By developing a novel MRI-assisted procedure that reliably localizes recorded single neurons at resolution of six individual layers in monkey temporal cortex, we show that transformation of representations from a cued object to a to-be-recalled object occurs at the infragranular layer in a visual cued-recall task. This cue-to-target conversion started in layer 5 and was followed by layer 6. Finally, a subset of layer 6 neurons exclusively encoding the sought target became phase-locked to surrounding field potentials at theta frequency, suggesting that this coordinated cell assembly implements cortical long-distance outputs of the recalled target. Thus, this study proposes a link from local computation spanning laminar modules of the temporal cortex to the brain-wide network for memory retrieval in primates.
Original language | English |
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Pages (from-to) | 518-529 |
Number of pages | 12 |
Journal | Neuron |
Volume | 92 |
Issue number | 2 |
DOIs | |
Publication status | Published - Oct 19 2016 |
Externally published | Yes |
Keywords
- cortical layer
- laminar localization
- memory retrieval
- microcircuit
- monkey
- MRI
- temporal cortex
ASJC Scopus subject areas
- Neuroscience(all)