We engineered Lactobacillus paracasei to produce a dsRNA that would trigger RNAi-induced silencing of an essential gene in the nematode Caenorhabditis elegans. The dsRNA-expressing L. paracasei can be used in experiments conducted on culture plates and may also be used as an orally administrable dsRNA carrier for humans and other mammals.
- Caenorhabditis elegans
- Lactic acid bacteria
- Lactobacillus paracasei
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology