Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse

Yoshinori Itoh; Ryozo Oishi; Masahiro Nishibori; Kiyomi Saeki; Katsushi Furuno; Tamotsu Fukuda; Yasunori Araki

doi:10.1016/0091-3057(86)90560-5

Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse

Yoshinori Itoh, Ryozo Oishi, Masahiro Nishibori, Kiyomi Saeki, Katsushi Furuno, Tamotsu Fukuda, Yasunori Araki

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The effects of L-histidine (HIS) on the hypermotility and the changes in brain monoamine dynamics induced by methamphetamine (MAMP) were examined in mice. HIS (1000 mg/kg) completely inhibited the hypermotility induced by MAMP (1 mg/kg). MAMP (1 mg/kg) significantly increased the dopamine level and decreased the 3,4-dihydroxyphenylacetic acid level. MAMP (5 and 10 mg/kg) also produced changes in the levels of noradrenaline, serotonin and their metabolites. HIS administered alone caused no significant changes in the levels of these amines and metabolites, nor did it affect MAMP-induced alterations in monoamine dynamics. These results suggest that catecholaminergic mechanisms are not involved in the behavioral anti-MAMP action of HIS.

Original language	English
Pages (from-to)	571-574
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(86)90560-5
Publication status	Published - Mar 1986

Keywords

Dopamine
Electrochemical detection
HPLC
L-histidine
Methamphetamine
Motor activity
Noradrenaline
Serotonin

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(86)90560-5

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title = "Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse",

abstract = "The effects of L-histidine (HIS) on the hypermotility and the changes in brain monoamine dynamics induced by methamphetamine (MAMP) were examined in mice. HIS (1000 mg/kg) completely inhibited the hypermotility induced by MAMP (1 mg/kg). MAMP (1 mg/kg) significantly increased the dopamine level and decreased the 3,4-dihydroxyphenylacetic acid level. MAMP (5 and 10 mg/kg) also produced changes in the levels of noradrenaline, serotonin and their metabolites. HIS administered alone caused no significant changes in the levels of these amines and metabolites, nor did it affect MAMP-induced alterations in monoamine dynamics. These results suggest that catecholaminergic mechanisms are not involved in the behavioral anti-MAMP action of HIS.",

keywords = "Dopamine, Electrochemical detection, HPLC, L-histidine, Methamphetamine, Motor activity, Noradrenaline, Serotonin",

author = "Yoshinori Itoh and Ryozo Oishi and Masahiro Nishibori and Kiyomi Saeki and Katsushi Furuno and Tamotsu Fukuda and Yasunori Araki",

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AU - Itoh, Yoshinori

AU - Oishi, Ryozo

AU - Nishibori, Masahiro

AU - Saeki, Kiyomi

AU - Furuno, Katsushi

AU - Fukuda, Tamotsu

AU - Araki, Yasunori

PY - 1986/3

Y1 - 1986/3

N2 - The effects of L-histidine (HIS) on the hypermotility and the changes in brain monoamine dynamics induced by methamphetamine (MAMP) were examined in mice. HIS (1000 mg/kg) completely inhibited the hypermotility induced by MAMP (1 mg/kg). MAMP (1 mg/kg) significantly increased the dopamine level and decreased the 3,4-dihydroxyphenylacetic acid level. MAMP (5 and 10 mg/kg) also produced changes in the levels of noradrenaline, serotonin and their metabolites. HIS administered alone caused no significant changes in the levels of these amines and metabolites, nor did it affect MAMP-induced alterations in monoamine dynamics. These results suggest that catecholaminergic mechanisms are not involved in the behavioral anti-MAMP action of HIS.

AB - The effects of L-histidine (HIS) on the hypermotility and the changes in brain monoamine dynamics induced by methamphetamine (MAMP) were examined in mice. HIS (1000 mg/kg) completely inhibited the hypermotility induced by MAMP (1 mg/kg). MAMP (1 mg/kg) significantly increased the dopamine level and decreased the 3,4-dihydroxyphenylacetic acid level. MAMP (5 and 10 mg/kg) also produced changes in the levels of noradrenaline, serotonin and their metabolites. HIS administered alone caused no significant changes in the levels of these amines and metabolites, nor did it affect MAMP-induced alterations in monoamine dynamics. These results suggest that catecholaminergic mechanisms are not involved in the behavioral anti-MAMP action of HIS.

KW - Dopamine

KW - Electrochemical detection

KW - HPLC

KW - L-histidine

KW - Methamphetamine

KW - Motor activity

KW - Noradrenaline

KW - Serotonin

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JO - Pharmacology, Biochemistry and Behavior

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ER -

Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse

Abstract

Keywords

ASJC Scopus subject areas

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