Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse

Yoshinori Itoh, Ryozo Oishi, Masahiro Nishibori, Kiyomi Saeki, Katsushi Furuno, Tamotsu Fukuda, Yasunori Araki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of L-histidine (HIS) on the hypermotility and the changes in brain monoamine dynamics induced by methamphetamine (MAMP) were examined in mice. HIS (1000 mg/kg) completely inhibited the hypermotility induced by MAMP (1 mg/kg). MAMP (1 mg/kg) significantly increased the dopamine level and decreased the 3,4-dihydroxyphenylacetic acid level. MAMP (5 and 10 mg/kg) also produced changes in the levels of noradrenaline, serotonin and their metabolites. HIS administered alone caused no significant changes in the levels of these amines and metabolites, nor did it affect MAMP-induced alterations in monoamine dynamics. These results suggest that catecholaminergic mechanisms are not involved in the behavioral anti-MAMP action of HIS.

Original languageEnglish
Pages (from-to)571-574
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume24
Issue number3
DOIs
Publication statusPublished - 1986

Fingerprint

Methamphetamine
Histidine
Metabolites
3,4-Dihydroxyphenylacetic Acid
Amines
Dopamine
Brain
Serotonin
Norepinephrine

Keywords

  • Dopamine
  • Electrochemical detection
  • HPLC
  • L-histidine
  • Methamphetamine
  • Motor activity
  • Noradrenaline
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse. / Itoh, Yoshinori; Oishi, Ryozo; Nishibori, Masahiro; Saeki, Kiyomi; Furuno, Katsushi; Fukuda, Tamotsu; Araki, Yasunori.

In: Pharmacology Biochemistry and Behavior, Vol. 24, No. 3, 1986, p. 571-574.

Research output: Contribution to journalArticle

Itoh, Yoshinori ; Oishi, Ryozo ; Nishibori, Masahiro ; Saeki, Kiyomi ; Furuno, Katsushi ; Fukuda, Tamotsu ; Araki, Yasunori. / Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse. In: Pharmacology Biochemistry and Behavior. 1986 ; Vol. 24, No. 3. pp. 571-574.
@article{d6c9f7363a2e45308c910efc4990760c,
title = "Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse",
abstract = "The effects of L-histidine (HIS) on the hypermotility and the changes in brain monoamine dynamics induced by methamphetamine (MAMP) were examined in mice. HIS (1000 mg/kg) completely inhibited the hypermotility induced by MAMP (1 mg/kg). MAMP (1 mg/kg) significantly increased the dopamine level and decreased the 3,4-dihydroxyphenylacetic acid level. MAMP (5 and 10 mg/kg) also produced changes in the levels of noradrenaline, serotonin and their metabolites. HIS administered alone caused no significant changes in the levels of these amines and metabolites, nor did it affect MAMP-induced alterations in monoamine dynamics. These results suggest that catecholaminergic mechanisms are not involved in the behavioral anti-MAMP action of HIS.",
keywords = "Dopamine, Electrochemical detection, HPLC, L-histidine, Methamphetamine, Motor activity, Noradrenaline, Serotonin",
author = "Yoshinori Itoh and Ryozo Oishi and Masahiro Nishibori and Kiyomi Saeki and Katsushi Furuno and Tamotsu Fukuda and Yasunori Araki",
year = "1986",
doi = "10.1016/0091-3057(86)90560-5",
language = "English",
volume = "24",
pages = "571--574",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse

AU - Itoh, Yoshinori

AU - Oishi, Ryozo

AU - Nishibori, Masahiro

AU - Saeki, Kiyomi

AU - Furuno, Katsushi

AU - Fukuda, Tamotsu

AU - Araki, Yasunori

PY - 1986

Y1 - 1986

N2 - The effects of L-histidine (HIS) on the hypermotility and the changes in brain monoamine dynamics induced by methamphetamine (MAMP) were examined in mice. HIS (1000 mg/kg) completely inhibited the hypermotility induced by MAMP (1 mg/kg). MAMP (1 mg/kg) significantly increased the dopamine level and decreased the 3,4-dihydroxyphenylacetic acid level. MAMP (5 and 10 mg/kg) also produced changes in the levels of noradrenaline, serotonin and their metabolites. HIS administered alone caused no significant changes in the levels of these amines and metabolites, nor did it affect MAMP-induced alterations in monoamine dynamics. These results suggest that catecholaminergic mechanisms are not involved in the behavioral anti-MAMP action of HIS.

AB - The effects of L-histidine (HIS) on the hypermotility and the changes in brain monoamine dynamics induced by methamphetamine (MAMP) were examined in mice. HIS (1000 mg/kg) completely inhibited the hypermotility induced by MAMP (1 mg/kg). MAMP (1 mg/kg) significantly increased the dopamine level and decreased the 3,4-dihydroxyphenylacetic acid level. MAMP (5 and 10 mg/kg) also produced changes in the levels of noradrenaline, serotonin and their metabolites. HIS administered alone caused no significant changes in the levels of these amines and metabolites, nor did it affect MAMP-induced alterations in monoamine dynamics. These results suggest that catecholaminergic mechanisms are not involved in the behavioral anti-MAMP action of HIS.

KW - Dopamine

KW - Electrochemical detection

KW - HPLC

KW - L-histidine

KW - Methamphetamine

KW - Motor activity

KW - Noradrenaline

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0022650865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022650865&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(86)90560-5

DO - 10.1016/0091-3057(86)90560-5

M3 - Article

VL - 24

SP - 571

EP - 574

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 3

ER -