L-Aspartate-evoked inhibition of melatonin production in rat pineal glands

Hiroshi Yamada, Akihito Yamaguchi, Yoshinori Moriyama

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Our previous studies in rat indicated that pinealocytes secrete L glutamate through microvesicle-mediated exocytosis to regulate negatively melatonin production. Recently, we further found that pinealocytes secrete L- aspartate through microvesicle-mediated exocytosis. In the present study, we investigated the role of L-aspartate in the melatonin production in isolated rat pineal glands. It was found that L-aspartate inhibits norepinephrine- stimulated melatonin production as well as serotonin N-acetyltransferase activity reversibly and dose dependently, the concentrations required for 50% inhibition being 150 and 175 μM, respectively, L-Asparagine and oxaloacetate, metabolites of L-aspartate, had no effect on the melatonin production. These results suggest that pinealocytes use L-aspartate, as well as M glutamate, as a negative regulator for melatonin production.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalNeuroscience Letters
Volume228
Issue number2
DOIs
Publication statusPublished - Jun 6 1997

Keywords

  • Exocytosis
  • L-Aspartate
  • L-Glutamate
  • Melatonin
  • Microvesicles
  • Pineal gland

ASJC Scopus subject areas

  • Neuroscience(all)

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