Abstract
We developed an efficient acylative kinetic resolution of 3-hydroxy-3-substituted 2-oxindoles by a chiral DMAP derivative having a 1,1′-binaphthyl with two tert-alcohols units. A wide range of 3-hydroxy-3-substituted oxindoles having various functional groups were efficiently resolved (14 examples, up to s = 60) in the presence of 1 mol % of catalyst within 3−9 h. Multigram-scale reactions (10 g) also proceeded with a high s-factor (s = 43) within 5 h.
Original language | English |
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Journal | Organic Letters |
DOIs | |
Publication status | Accepted/In press - 2021 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry