Kinetic resolution of secondary alcohols by the combination of a chiral Brønsted acid, DABCO, and acetyl chloride

Hiroki Mandai, Kyouta Murota, Koichi Mitsudo, Seiji Suga

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

An efficient and simple protocol for the kinetic resolution of secondary alcohols is presented. The new system is based on a combination of chiral Brønsted acid, DABCO, and acetyl chloride and gives various enantioenriched alcohols with selectivity factors up to 105.

Original languageEnglish
Pages (from-to)3486-3489
Number of pages4
JournalOrganic Letters
Volume14
Issue number13
DOIs
Publication statusPublished - Jul 6 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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