Kinetic resolution of 5-(hydroxymethyl)-3-phenyl-2-isoxazoline by using the 'low-temperature method' with porous ceramic-immobilized lipase

Takashi Sakai, Hiroshi Mitsutomi, Toshinobu Korenaga, Tadashi Ema

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6 Citations (Scopus)

Abstract

A significant enhancement of the enantioselectivity (E value = 249) in the lipase-catalyzed resolution of a primary alcohol, racemic 5-(hydroxymethyl)-3- phenyl-2-isoxazoline (±)-1, was obtained by using the 'low-temperature method' (-60°C) with porous ceramic-immobilized lipase (Amano PS-C II) and vinyl acetate in acetone.

Original languageEnglish
Pages (from-to)1535-1539
Number of pages5
JournalTetrahedron Asymmetry
Volume16
Issue number8
DOIs
Publication statusPublished - Apr 18 2005

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ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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