TY - JOUR
T1 - Kinetic resolution of 5-(hydroxymethyl)-3-phenyl-2-isoxazoline by using the 'low-temperature method' with porous ceramic-immobilized lipase
AU - Sakai, Takashi
AU - Mitsutomi, Hiroshi
AU - Korenaga, Toshinobu
AU - Ema, Tadashi
N1 - Funding Information:
This work was partially supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. We are grateful to the SC-NMR Laboratory of Okayama University for the measurement of 500 MHz 1 H NMR spectra.
PY - 2005/4/18
Y1 - 2005/4/18
N2 - A significant enhancement of the enantioselectivity (E value = 249) in the lipase-catalyzed resolution of a primary alcohol, racemic 5-(hydroxymethyl)-3- phenyl-2-isoxazoline (±)-1, was obtained by using the 'low-temperature method' (-60°C) with porous ceramic-immobilized lipase (Amano PS-C II) and vinyl acetate in acetone.
AB - A significant enhancement of the enantioselectivity (E value = 249) in the lipase-catalyzed resolution of a primary alcohol, racemic 5-(hydroxymethyl)-3- phenyl-2-isoxazoline (±)-1, was obtained by using the 'low-temperature method' (-60°C) with porous ceramic-immobilized lipase (Amano PS-C II) and vinyl acetate in acetone.
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U2 - 10.1016/j.tetasy.2005.02.025
DO - 10.1016/j.tetasy.2005.02.025
M3 - Article
AN - SCOPUS:17044408666
SN - 0957-4166
VL - 16
SP - 1535
EP - 1539
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 8
ER -