Kinetic analysis of neuromuscular blockade. II. Train-of-four fade induced by d-tubocurarine and α-bungarotoxin

T. Tajima, Y. Kato, T. Hatanaka, Tetsuya Aiba, K. Katayama, T. Koizumi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions: (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can he explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.

Original languageEnglish
Pages (from-to)1089-1093
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume17
Issue number8
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Bungarotoxins
Tubocurarine
Neuromuscular Blockade
Acetylcholine
Nicotinic Receptors
Cholinergic Receptors
Muscles

Keywords

  • α-bungarotoxin
  • acetylcholine
  • d-tubocurarine
  • pha rmacokinetics
  • pharmacodynamics
  • train-of-four fade

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kinetic analysis of neuromuscular blockade. II. Train-of-four fade induced by d-tubocurarine and α-bungarotoxin. / Tajima, T.; Kato, Y.; Hatanaka, T.; Aiba, Tetsuya; Katayama, K.; Koizumi, T.

In: Biological and Pharmaceutical Bulletin, Vol. 17, No. 8, 1994, p. 1089-1093.

Research output: Contribution to journalArticle

Tajima, T. ; Kato, Y. ; Hatanaka, T. ; Aiba, Tetsuya ; Katayama, K. ; Koizumi, T. / Kinetic analysis of neuromuscular blockade. II. Train-of-four fade induced by d-tubocurarine and α-bungarotoxin. In: Biological and Pharmaceutical Bulletin. 1994 ; Vol. 17, No. 8. pp. 1089-1093.
@article{8b7ef4aaf75047edbd9bfbad7153126b,
title = "Kinetic analysis of neuromuscular blockade. II. Train-of-four fade induced by d-tubocurarine and α-bungarotoxin",
abstract = "The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions: (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can he explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.",
keywords = "α-bungarotoxin, acetylcholine, d-tubocurarine, pha rmacokinetics, pharmacodynamics, train-of-four fade",
author = "T. Tajima and Y. Kato and T. Hatanaka and Tetsuya Aiba and K. Katayama and T. Koizumi",
year = "1994",
language = "English",
volume = "17",
pages = "1089--1093",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
number = "8",

}

TY - JOUR

T1 - Kinetic analysis of neuromuscular blockade. II. Train-of-four fade induced by d-tubocurarine and α-bungarotoxin

AU - Tajima, T.

AU - Kato, Y.

AU - Hatanaka, T.

AU - Aiba, Tetsuya

AU - Katayama, K.

AU - Koizumi, T.

PY - 1994

Y1 - 1994

N2 - The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions: (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can he explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.

AB - The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions: (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can he explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.

KW - α-bungarotoxin

KW - acetylcholine

KW - d-tubocurarine

KW - pha rmacokinetics

KW - pharmacodynamics

KW - train-of-four fade

UR - http://www.scopus.com/inward/record.url?scp=0028024981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028024981&partnerID=8YFLogxK

M3 - Article

C2 - 7820114

AN - SCOPUS:0028024981

VL - 17

SP - 1089

EP - 1093

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 8

ER -