Kinetic Analysis of Neuromuscular Blockade. II. Train-of-Four Fade Induced by d-Tubocurarine and α-Bungarotoxin

Takeshi Tajima, Yasuhiro Kato, Tomomi Hatanaka, Tetsuya Aiba, Kazunori Katayama, Tamotsu Komumi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions: (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can be explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.

Original languageEnglish
Pages (from-to)1089-1093
Number of pages5
JournalBiological and Pharmaceutical Bulletin
Volume17
Issue number8
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

Keywords

  • a-bungarotoxin
  • acetylcholine
  • d-tubocurarine
  • pharmacodynamics
  • pharmacokinetics
  • train-of-four fade

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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