Kinetic Analysis of Neuromuscular Blockade. II. Train-of-Four Fade Induced by d-Tubocurarine and α-Bungarotoxin

Takeshi Tajima; Yasuhiro Kato; Tomomi Hatanaka; Tetsuya Aiba; Kazunori Katayama; Tamotsu Komumi

doi:10.1248/bpb.17.1089

Kinetic Analysis of Neuromuscular Blockade. II. Train-of-Four Fade Induced by d-Tubocurarine and α-Bungarotoxin

Takeshi Tajima, Yasuhiro Kato, Tomomi Hatanaka, Tetsuya Aiba, Kazunori Katayama, Tamotsu Komumi

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions: (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can be explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.

Original language	English
Pages (from-to)	1089-1093
Number of pages	5
Journal	Biological and Pharmaceutical Bulletin
Volume	17
Issue number	8
DOIs	https://doi.org/10.1248/bpb.17.1089
Publication status	Published - 1994
Externally published	Yes

Keywords

a-bungarotoxin
acetylcholine
d-tubocurarine
pharmacodynamics
pharmacokinetics
train-of-four fade

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.17.1089

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title = "Kinetic Analysis of Neuromuscular Blockade. II. Train-of-Four Fade Induced by d-Tubocurarine and α-Bungarotoxin",

abstract = "The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions: (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can be explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.",

keywords = "a-bungarotoxin, acetylcholine, d-tubocurarine, pharmacodynamics, pharmacokinetics, train-of-four fade",

author = "Takeshi Tajima and Yasuhiro Kato and Tomomi Hatanaka and Tetsuya Aiba and Kazunori Katayama and Tamotsu Komumi",

year = "1994",

doi = "10.1248/bpb.17.1089",

language = "English",

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AU - Tajima, Takeshi

AU - Kato, Yasuhiro

AU - Hatanaka, Tomomi

AU - Aiba, Tetsuya

AU - Katayama, Kazunori

AU - Komumi, Tamotsu

PY - 1994

Y1 - 1994

N2 - The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions: (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can be explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.

AB - The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and α-bungarotoxin (α-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by α-BX, and the difference was analyzed using a kinetic model. Based on the assumptions: (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) α-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and α-BX can be explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.

KW - a-bungarotoxin

KW - acetylcholine

KW - d-tubocurarine

KW - pharmacodynamics

KW - pharmacokinetics

KW - train-of-four fade

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Kinetic Analysis of Neuromuscular Blockade. II. Train-of-Four Fade Induced by d-Tubocurarine and α-Bungarotoxin

Abstract

Keywords

ASJC Scopus subject areas

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