Kinetic Analysis of Neuromuscular Blockade. I. Relationship between Twitch Depression and Stimulation Frequency after d-Tubocurarine Administration

Takeshi Tajima, Kazuyo Kaneko, Tomomi Hatanaka, Tetsuya Aiba, Kazunori Katayama, Tamotsu Koizumi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The degree of twitch depression induced by nondepolarizing neuromuscular blocking drugs is known to be dependent on the stimulation frequency employed. Train-of-four (TOF) stimulations with different frequencies (0.67, 1.33 and 2.0 Hz) were delivered to a sciatic nerve of a rat and series of four twitch heights of a tibialis anterior muscle were measured after d-tubocurarine (d-TC) administration. With a decrease of stimulus interval, twitch heights were intensely depressed. We hypothesized that the oservations are due to the changes of released amount of neuromuscular transmitter, acetylcholine, dependent on stimulus interval, and a pharmacokinetic/pharmacodynamic model based on the hypothesis was proposed. The model allowed simultaneous fitting of the twitch height depression after d-TC administration. It also could give a rationale to the fact that TOF stimulation at 2.0 Hz is a more sensitive monitoring method of neuromuscular function than single twitch stimulation (0.1—0.2 Hz).

Original languageEnglish
Pages (from-to)1083-1088
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume17
Issue number8
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

Keywords

  • acetylcholine
  • d-tubocurarine
  • neuromuscular blocking drug
  • pharmacodynamics
  • pharmacokinetics
  • train-of-four stimulation

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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