Kindling-induced persistent alterations in the membrane and synaptic properties of CA1 pyramidal neurons

Norihito Yamada, David K. Bilkey

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Intracellular recordings of CA1 pyramidal cells were performed in in vitro hippocampal slices obtained from control and amygdala- or perforant path-kindled rats. Passive membrane properties did not differ between control and kindled cells. Twenty-three percent of kindled cells, however, displayed burst firing with depolarizing current injection, whereas no control cells produced bursts (P <0.01). Two different types of voltage-dependent alteration of depolarizing postsynaptic potentials (PSPs) were also evident in kindled cells. The majority (26/29) of these cells showed a smaller increase (type 1, n = 18), or a sudden decrease (type 2, n = 8), in PSP amplitude with passive membrane hyperpolarization when compared to controls (P <0.01). The NMDA antagonist D-APV did not markedly alter the overall slope of the PSP/membrane potential function in either 'type 1' or 'type 2' cells, suggesting that neither behavior was due to a change in the activation characteristics of NMDA receptors. The amplitude of IPSPs was smaller in 'type 1' kindled cells (P <0.05) than in controls, however, suggesting that the reduced slope of the PSP/membrane function may be accounted for by a change in inhibition.

Original languageEnglish
Pages (from-to)324-331
Number of pages8
JournalBrain Research
Volume561
Issue number2
DOIs
Publication statusPublished - Oct 11 1991
Externally publishedYes

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Synaptic Membranes
Pyramidal Cells
Synaptic Potentials
Membranes
Perforant Pathway
Inhibitory Postsynaptic Potentials
N-Methylaspartate
Amygdala
N-Methyl-D-Aspartate Receptors
Membrane Potentials
Injections

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Kindling-induced persistent alterations in the membrane and synaptic properties of CA1 pyramidal neurons. / Yamada, Norihito; Bilkey, David K.

In: Brain Research, Vol. 561, No. 2, 11.10.1991, p. 324-331.

Research output: Contribution to journalArticle

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