Kindling-induced persistent alterations in the membrane and synaptic properties of CA1 pyramidal neurons

Norihito Yamada, David K. Bilkey

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Abstract

Intracellular recordings of CA1 pyramidal cells were performed in in vitro hippocampal slices obtained from control and amygdala- or perforant path-kindled rats. Passive membrane properties did not differ between control and kindled cells. Twenty-three percent of kindled cells, however, displayed burst firing with depolarizing current injection, whereas no control cells produced bursts (P < 0.01). Two different types of voltage-dependent alteration of depolarizing postsynaptic potentials (PSPs) were also evident in kindled cells. The majority (26/29) of these cells showed a smaller increase (type 1, n = 18), or a sudden decrease (type 2, n = 8), in PSP amplitude with passive membrane hyperpolarization when compared to controls (P < 0.01). The NMDA antagonist D-APV did not markedly alter the overall slope of the PSP/membrane potential function in either 'type 1' or 'type 2' cells, suggesting that neither behavior was due to a change in the activation characteristics of NMDA receptors. The amplitude of IPSPs was smaller in 'type 1' kindled cells (P < 0.05) than in controls, however, suggesting that the reduced slope of the PSP/membrane function may be accounted for by a change in inhibition.

Original languageEnglish
Pages (from-to)324-331
Number of pages8
JournalBrain Research
Volume561
Issue number2
DOIs
Publication statusPublished - Oct 11 1991
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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