Kinase inhibitors and their resistance

Yosuke Togashi, Kazuto Nishio

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Kinase cascades are involved in all stages of tumorigenesis through modulation of transformation and differentiation, cell-cycle progression, and motility. Advances in molecular targeted drug development allow the design and synthesis of inhibitors targeting cancer-associated signal transduction pathways. Potent selective inhibitors with low toxicity can benefit patients especially with several malignancies harboring an oncogenic driver addictive signal. This article evaluates information on solid tumor-related kinase signals and inhibitors, including receptor tyrosine kinase or serine/threonine kinase signals that lead to successful application in clinical settings. In addition, the resistant mechanisms to the inhibitors is summarized.

Original languageEnglish
Pages (from-to)1323-1329
Number of pages7
JournalNihon rinsho. Japanese journal of clinical medicine
Volume73
Issue number8
Publication statusPublished - Aug 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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