Kikuchi-Fujimoto disease: evaluation of prognostic factors and analysis of pathologic findings

Hidenori Marunaka, Yorihisa Orita, Tomoyasu Tachibana, Kentaro Miki, Takuma Makino, Yuka Gion, Kazunori Nishizaki, Tadashi Yoshino, Yasuharu Sato

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Conclusion: In Kikuchi-Fujimoto disease (KFD), a low ratio of blastic cells (<70%) in lymph node specimens and absence of atypical lymphocytes in peripheral blood are predictive of a protracted clinical course. Objectives: Since KFD is a self-limiting disorder that does not require any specific management, prognostic factors have received little attention. The present study identified clinical and pathological factors that may affect the period from onset to cure of KFD. Methods: This retrospective study investigated 43 KFD patients who underwent lymph node biopsy diagnosed by immunohistochemical staining at Okayama University Hospital and Okayama Medical Center from January 2001 to December 2013. Results: Mean total period from onset to cure was 6 months (median =9.4 months; range =1–37 months). Low ratios of blastic cell proliferation area (<70%) in lymph node specimens (p = 0.011) and absence of atypical lymphocytes in peripheral blood (p = 0.026) were associated with a relatively long duration of KFD.

Original languageEnglish
Pages (from-to)944-947
Number of pages4
JournalActa Oto-Laryngologica
Volume136
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • Kikuchi-Fujimoto disease
  • atypical lymphocytes
  • blastic cell
  • prognostic factors

ASJC Scopus subject areas

  • Otorhinolaryngology

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