Kikuchi-Fujimoto disease complicated with reactive hemophagocytic lymphohistiocytosis

Masatake Nishiwaki, Hideharu Hagiya, Toru Kamiya

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Methylguanidine (MG) is a known nephrotoxin and neurotoxin, and an intracisternal injection of MG can induce convulsions in experimental animals. In this in vitro study, we examined the inhibitory effects of the antiepileptic agent zonisamide (ZNS) on hydroxyl radicals (•OH) generated from MG by using an electron spin resonance (ESR) technique. ZNS scavenged •OH generated from MG in a dose-dependent manner through direct scavenging during the auto-oxidation of MG. The rate constant of ZNS reacting with the •OH was at a near diffusion-controlled rate. These findings indicate that ZNS might detoxify MG and could thus protect against convulsive disorders.

Original languageEnglish
Pages (from-to)383-388
Number of pages6
JournalActa medica Okayama
Volume70
Issue number5
Publication statusPublished - Jan 1 2016
Externally publishedYes

Keywords

  • Hemophagocytic lymphohistiocytosis
  • Hemophagocytic syndrome
  • Histiocytic necrotizing lymphadenitis
  • Kikuchi disease
  • Kikuchi-Fujimoto disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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