Kidney, fluid, and acid-base balance

Naohiro Shioji, Masao Hayashi, Hiroshi Morimatsu

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Kidneys play an important role to maintain human homeostasis. They contribute to maintain body fluid, electrolytes, and acid-base balance. Especially in fluid control, we, physicians can intervene body fluid balance using fluid resuscitation and diuretics. In recent years, one type of fluid resuscitation, hydroxyl ethyl starch has been extensively studied in the field of intensive care. Although their effects on fluid resuscitation are reasonable, serious complications such as kidney injury requiring renal replacement therapy occur frequently. Now we have to pay more attention to this important complication. Another topic of fluid management is tolvaptan, a selective vasopressin-2 receptor antagonist Recent randomized trial suggested that tolvaptan has a similar supportive effect for fluid control and more cost effective compared to carperitide. In recent years, Stewart approach is recognized as one important tool to assess acid-base balance in critically ill patients. This approach has great value, especially to understand metabolic components in acid-base balance. Even for assessing the effects of kidneys on acid-base balance, this approach gives us interesting insight We should appropriately use this new approach to treat acid-base abnormality in critically ill patients.

Original languageEnglish
Pages (from-to)503-510
Number of pages8
JournalJapanese Journal of Anesthesiology
Issue number5
Publication statusPublished - May 2016


  • Acid-base balance
  • Fluid
  • Kidney
  • Stewart approach

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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