Ki-1+ Cutaneous Lymphoma: Gene Rearrangement Analysis of Tumor Cells in Tissue and Short-term Culture of a Patient

Higashi Sugimoto, Fukiko Nakayama, Takashi Yamauchi, Yoshiki Tokura, Keiji Iwatsuki, Masahiro Takigawa, Mizuho Yamada, Michiyuki Maeda

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18 Citations (Scopus)

Abstract

Cutaneous malignant lymphomas developed in an 80-year-old man without any evidence of leukemic disseminations of lymphoma cells. Immunohistologic staining showed the expression of Leu-3a, Leu-4, Ki-1, Tac, and HLA-DR antigens on tumor cells in tissue and large lymphoid cells in long-term, interleukin 2-containing culture of tumor explants. DNA samples extracted from the skin tumors and cultured lymphoid cells showed a clonal rearrangement of T-cell receptor (TCR) gene Cβ1 with the molecular size of 9 kilobases. These findings suggested the T-cell origin of Ki-1+ cutaneous lymphoma cells and the occurrence of a clonal proliferation of tumor cells in culture.

Original languageEnglish
Pages (from-to)405-408
Number of pages4
JournalArchives of Dermatology
Volume124
Issue number3
DOIs
Publication statusPublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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    Sugimoto, H., Nakayama, F., Yamauchi, T., Tokura, Y., Iwatsuki, K., Takigawa, M., Yamada, M., & Maeda, M. (1988). Ki-1+ Cutaneous Lymphoma: Gene Rearrangement Analysis of Tumor Cells in Tissue and Short-term Culture of a Patient. Archives of Dermatology, 124(3), 405-408. https://doi.org/10.1001/archderm.124.3.405