Ki-1+ Cutaneous Lymphoma: Gene Rearrangement Analysis of Tumor Cells in Tissue and Short-term Culture of a Patient

Higashi Sugimoto, Fukiko Nakayama, Takashi Yamauchi, Yoshiki Tokura, Keiji Iwatsuki, Masahiro Takigawa, Mizuho Yamada, Michiyuki Maeda

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cutaneous malignant lymphomas developed in an 80-year-old man without any evidence of leukemic disseminations of lymphoma cells. Immunohistologic staining showed the expression of Leu-3a, Leu-4, Ki-1, Tac, and HLA-DR antigens on tumor cells in tissue and large lymphoid cells in long-term, interleukin 2-containing culture of tumor explants. DNA samples extracted from the skin tumors and cultured lymphoid cells showed a clonal rearrangement of T-cell receptor (TCR) gene Cβ1 with the molecular size of 9 kilobases. These findings suggested the T-cell origin of Ki-1+ cutaneous lymphoma cells and the occurrence of a clonal proliferation of tumor cells in culture.

Original languageEnglish
Pages (from-to)405-408
Number of pages4
JournalArchives of Dermatology
Volume124
Issue number3
DOIs
Publication statusPublished - Jan 1 1988
Externally publishedYes

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Anaplastic Large-Cell Lymphoma
Gene Rearrangement
Skin
Lymphoma
Neoplasms
Lymphocytes
T-Cell Receptor Genes
HLA-DR Antigens
Interleukin-2
Cultured Cells
Cell Culture Techniques
Staining and Labeling
T-Lymphocytes
DNA

ASJC Scopus subject areas

  • Dermatology

Cite this

Sugimoto, H., Nakayama, F., Yamauchi, T., Tokura, Y., Iwatsuki, K., Takigawa, M., ... Maeda, M. (1988). Ki-1+ Cutaneous Lymphoma: Gene Rearrangement Analysis of Tumor Cells in Tissue and Short-term Culture of a Patient. Archives of Dermatology, 124(3), 405-408. https://doi.org/10.1001/archderm.124.3.405

Ki-1+ Cutaneous Lymphoma : Gene Rearrangement Analysis of Tumor Cells in Tissue and Short-term Culture of a Patient. / Sugimoto, Higashi; Nakayama, Fukiko; Yamauchi, Takashi; Tokura, Yoshiki; Iwatsuki, Keiji; Takigawa, Masahiro; Yamada, Mizuho; Maeda, Michiyuki.

In: Archives of Dermatology, Vol. 124, No. 3, 01.01.1988, p. 405-408.

Research output: Contribution to journalArticle

Sugimoto, H, Nakayama, F, Yamauchi, T, Tokura, Y, Iwatsuki, K, Takigawa, M, Yamada, M & Maeda, M 1988, 'Ki-1+ Cutaneous Lymphoma: Gene Rearrangement Analysis of Tumor Cells in Tissue and Short-term Culture of a Patient', Archives of Dermatology, vol. 124, no. 3, pp. 405-408. https://doi.org/10.1001/archderm.124.3.405
Sugimoto, Higashi ; Nakayama, Fukiko ; Yamauchi, Takashi ; Tokura, Yoshiki ; Iwatsuki, Keiji ; Takigawa, Masahiro ; Yamada, Mizuho ; Maeda, Michiyuki. / Ki-1+ Cutaneous Lymphoma : Gene Rearrangement Analysis of Tumor Cells in Tissue and Short-term Culture of a Patient. In: Archives of Dermatology. 1988 ; Vol. 124, No. 3. pp. 405-408.
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