Karyotypic analysis of bone marrow cells in pyodermic lesions associated with myelodysplastic syndrome

Toshihisa Hamada, Hironori Matsuura, Takashi Oono, Shin Morizane, Osamu Yamasaki, Kenji Asagoe, Takenobu Yamamoto, Kazuhide Tsuji, Keiji Iwatsuki

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Abstract

Background: Recalcitrant pyodermic lesions and neutrophilic dermatoses are often associated with subclinical myelodysplastic syndrome (MDS). In this case series, we assessed the diagnostic importance of karyotypic analysis of bone marrow cells in 4 patients with MDS-associated pyodermic eruptions treated at our university hospital. Karyotypic analysis was performed in bone marrow cells and peripheral blood lymphocytes obtained. Serum levels of granulocyte colony-stimulating factor were measured. Observations: Four patients with pyodermic eruptions or neutrophilic dermatosis had chromosomal abnormalities in bone marrow cells, including del(20)(q11;q13.3) in 2 patients, trisomy 8 in 1 patient, and t(11;22) (q23;q11) in 1 patient. Three patients without morphologic findings suggestive of MDS were diagnosed as having refractory anemia. One female patient had refractory anemia with ringed sideroblasts associated with del(20). Two patients with refractory anemia had a normal karyotype in peripheral blood lymphocytes. Two patients with elevated serum levels of granulocyte colony-stimulating factor had more active or widespread cutaneous diseases. Conclusions: Karyotypic analysis of bone marrow cells, but not of peripheral blood lymphocytes, is essential in proving a diagnosis of MDS-associated pyodermic lesions. The overexpression of granulocyte colony-stimulating factor, which may compensate for impaired hematopoiesis in patients with MDS, seems to be a key cytokine leading to neutrophilic infiltration.

Original languageEnglish
Pages (from-to)643-648
Number of pages6
JournalArchives of Dermatology
Volume144
Issue number5
DOIs
Publication statusPublished - May 2008

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Myelodysplastic Syndromes
Bone Marrow Cells
Refractory Anemia
Granulocyte Colony-Stimulating Factor
Skin Diseases
Lymphocytes
Hematopoiesis
Serum
Karyotype
Chromosome Aberrations
Cytokines

ASJC Scopus subject areas

  • Dermatology

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Karyotypic analysis of bone marrow cells in pyodermic lesions associated with myelodysplastic syndrome. / Hamada, Toshihisa; Matsuura, Hironori; Oono, Takashi; Morizane, Shin; Yamasaki, Osamu; Asagoe, Kenji; Yamamoto, Takenobu; Tsuji, Kazuhide; Iwatsuki, Keiji.

In: Archives of Dermatology, Vol. 144, No. 5, 05.2008, p. 643-648.

Research output: Contribution to journalArticle

Hamada, Toshihisa ; Matsuura, Hironori ; Oono, Takashi ; Morizane, Shin ; Yamasaki, Osamu ; Asagoe, Kenji ; Yamamoto, Takenobu ; Tsuji, Kazuhide ; Iwatsuki, Keiji. / Karyotypic analysis of bone marrow cells in pyodermic lesions associated with myelodysplastic syndrome. In: Archives of Dermatology. 2008 ; Vol. 144, No. 5. pp. 643-648.
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