Kaposi's sarcoma-associated herpesvirus is cell-intrinsically controlled in latency in microgravity

Tomoyuki Honda, Ryota Nakayama, Yumi Kawahara, Louis Yuge, Keiji Ueda

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


In the next several decades, humans will explore deep space, including Mars. During long-term space flight, astronauts will be exposed to various physical stressors. Among these stressors, microgravity may compromise the immune system. Consistently, the reactivation of several latent herpesviruses has been reported in astronauts. Although herpesvirus infection status is determined by both cell-intrinsic and -extrinsic factors, it remains unclear which factors play major roles in the virus reactivation in microgravity. Here, using Kaposi's sarcoma-associated herpesvirus (KSHV)-infected cells, we found that KSHV is cell-intrinsically controlled in latency in microgravity. Innate immunity appeared to be unaffected in microgravity, while the expression of some restriction factors against KSHV, such as CTCF and AMPK, was upregulated. Collectively, the infected cells in microgravity can control KSHV in latency, possibly by unimpaired innate immunity and upregulated KSHV restriction factors. This is the first pilot study of the conflicts between cell-intrinsic defense systems and viruses in microgravity and provides fundamental information regarding host-virus interactions in microgravity.

Original languageEnglish
Article number197821
JournalVirus research
Publication statusPublished - Jan 15 2020
Externally publishedYes


  • Cell-intrinsic
  • Innate immunity
  • Kaposi's sarcoma-associated herpesvirus
  • Microgravity
  • Viral replication

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases


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