Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice

Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yousuke Matsumoto, Motoi Okamoto, Shozo Aoki, Takeshi Ishihara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Many neuropsychiatric disorders develop in early life. Although the mechanisms involved have not been elucidated, it is possible that functional abnormalities of parvalbumin-positive interneurons (PV neurons) are present. Several previous studies have shown that juvenile stress is implicated in the development of neuropsychiatric disorders. We aimed to clarify the effects of juvenile stress on behavior and on the central nervous system. We investigated behavioral abnormalities of chronically-stressed mice during juvenilehood and the effect of juvenile stress on PV neurons and WFA-positive perineuronal nets (PNNs), which are associated with vulnerability and plasticity in the mouse brain. Results: Due to juvenile stress, mice showed neurodevelopmental disorder-like behavior. Juvenile stressed mice did not show depressive-like behaviors, but on the contrary, they showed increased activity and decreased anxiety-like behavior. In the central nervous system of juvenile stressed mice, the fluorescence intensity of WFA-positive PNNs decreased, which may signify increased vulnerability. Conclusion: This study suggested that juvenile stressed mice showed behavioral abnormalities, resembling those seen in neuropsychiatric disorders, and increased brain vulnerability.

Original languageEnglish
Article number41
JournalBMC Neuroscience
Volume19
Issue number1
DOIs
Publication statusPublished - Jul 16 2018

Fingerprint

Interneurons
Central Nervous System
Parvalbumins
Brain Diseases
Anxiety
Fluorescence
Brain
Neurodevelopmental Disorders

Keywords

  • Behavior
  • Juvenile
  • Mouse
  • Parvalbumin
  • Perineuronal nets
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice. / Ueno, Hiroshi; Suemitsu, Shunsuke; Murakami, Shinji; Kitamura, Naoya; Wani, Kenta; Matsumoto, Yousuke; Okamoto, Motoi; Aoki, Shozo; Ishihara, Takeshi.

In: BMC Neuroscience, Vol. 19, No. 1, 41, 16.07.2018.

Research output: Contribution to journalArticle

Ueno, H, Suemitsu, S, Murakami, S, Kitamura, N, Wani, K, Matsumoto, Y, Okamoto, M, Aoki, S & Ishihara, T 2018, 'Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice', BMC Neuroscience, vol. 19, no. 1, 41. https://doi.org/10.1186/s12868-018-0442-z
Ueno, Hiroshi ; Suemitsu, Shunsuke ; Murakami, Shinji ; Kitamura, Naoya ; Wani, Kenta ; Matsumoto, Yousuke ; Okamoto, Motoi ; Aoki, Shozo ; Ishihara, Takeshi. / Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice. In: BMC Neuroscience. 2018 ; Vol. 19, No. 1.
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