Juvenile granulosa cell tumor with an unusual clinical course: A late-onset and late recurrent case

Thar Htet San, Yoko Ota, Soichiro Fushimi, Masayoshi Fujisawa, Hiroyuki Yanai, Hiroko Toda, Tadayoshi Kunitomo, Keisuke Kodama, Akihiro Matsukawa

Research output: Contribution to journalArticle

Abstract

Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (~97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalActa medica Okayama
Volume74
Issue number2
Publication statusPublished - 2020

Keywords

  • Adult granulosa cell tumor
  • Juvenile granulosa cell tumor
  • Late recurrence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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