Jolkinolide D pharmacophore: Synthesis and reaction with biomolecules

Akira Sakakura, Yui Takayanagi, Hiroki Shimogawa, Hideo Kigoshi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

To obtain information on the chemical modification of biomolecules with jolkinolide D, a bioactive diterpenoid of plant origin, jolkinolide D pharmacophore was synthesized, and its reactivity toward amino acids, nucleosides, and DNA was investigated.

Original languageEnglish
Pages (from-to)7067-7075
Number of pages9
JournalTetrahedron
Volume60
Issue number33
DOIs
Publication statusPublished - Aug 9 2004
Externally publishedYes

Keywords

  • Alkylation
  • Diterpenoid
  • Jolkinolide D
  • Pharmacophore
  • Reactivity
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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