Jolkinolide D pharmacophore: Synthesis and reaction with amino acids, nucleosides, and DNA

Akira Sakakura, Yui Takayanagi, Hideo Kigoshi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

For the purpose of obtaining preliminary information on the chemical modification of biomolecules with jolkinolide D, a bioactive diterpenoid of plant origin, jolkinolide D pharmacophore, was synthesized and its reactivity toward amino acids, nucleosides, and DNA was investigated.

Original languageEnglish
Pages (from-to)6055-6058
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number34
DOIs
Publication statusPublished - Aug 19 2002
Externally publishedYes

Keywords

  • Diterpenoid
  • Jolkinolide D
  • Pharmacophore
  • Reactivity
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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