TY - JOUR
T1 - Japan Diabetic Nephropathy Cohort Study
T2 - Study design, methods, and implementation
AU - Furuichi, Kengo
AU - Shimizu, Miho
AU - Toyama, Tadashi
AU - Koya, Daisuke
AU - Koshino, Yoshitaka
AU - Abe, Hideharu
AU - Mori, Kiyoshi
AU - Satoh, Hiroaki
AU - Imanishi, Masahito
AU - Iwano, Masayuki
AU - Yamauchi, Hiroyuki
AU - Kusano, Eiji
AU - Fujimoto, Shouichi
AU - Suzuki, Yoshiki
AU - Okuda, Seiya
AU - Kitagawa, Kiyoki
AU - Iwata, Yasunori
AU - Kaneko, Shuichi
AU - Nishi, Shinichi
AU - Yokoyama, Hitoshi
AU - Ueda, Yoshihiko
AU - Haneda, Masakazu
AU - Makino, Hirofumi
AU - Wada, Takashi
N1 - Funding Information:
The researchers on the Committee for the Diabetic Nephropathy Research, which was supported by the Ministry of Health, Labour and Welfare of Japan, participated in this study. The report includes data from patients on the JRBR and JKDR, registered prospectively from January 2007. Patient data including age, gender, laboratory data, and clinical and pathological diagnoses were electronically recorded at each institution and registered on the web page of the JRBR and JKDR utilizing the system of Internet Data and Information Center for Medical Research (INDICE) in the University Hospital Medical Information Network (UMIN). JDNCS patient data were also electronically recorded at each institution and registered on the web page of the INDICE system in UMIN. The ethical committee of the Kanazawa University and the Japanese Society of Nephrology comprehensively approved the study, and a local committee of participating centers and their affiliated hospitals individually approved the study. Written informed consent was obtained from the patients at the time of biopsy or before participation in the study. The JRBR is registered to the Clinical Trial Registry of UMIN (registered number UMIN000000618) and is available in Japanese and English.
PY - 2013/12
Y1 - 2013/12
N2 - Background: Diabetic nephropathy, leading to end-stage renal disease, has a considerable impact on public health and the social economy. However, there are few national registries of diabetic nephropathy in Japan. The aims of this prospective cohort study are to obtain clinical data and urine samples for revising the clinical staging of diabetic nephropathy, and developing new diagnostic markers for early diabetic nephropathy. Methods: The Japanese Society of Nephrology established a nationwide, web-based, and prospective registry system. On the system, there are two basic registries; the Japan Renal Biopsy Registry (JRBR), and the Japan Kidney Disease Registry (JKDR). In addition to the two basic registries, we established a new prospective registry to the system; the Japan Diabetic Nephropathy Cohort Study (JDNCS), which collected physical and laboratory data. Results: We analyzed the data of 321 participants (106 female, 215 male; average age 65 years) in the JDNCS. Systolic and diastolic blood pressure was 130.1 and 72.3 mmHg, respectively. Median estimated glomerular filtration rate (eGFR) was 33.3 ml/min/1.73 m2. Proteinuria was 1.8 g/gCr, and serum levels of albumin were 3.6 g/dl. The majority of the JDNCS patients presented with preserved eGFR and low albuminuria or low eGFR and advanced proteinuria. In the JRBR and JKDR registries, 484 and 125 participants, respectively, were enrolled as having diabetes mellitus. In comparison with the JRBR and JKDR registries, the JDNCS was characterized by diabetic patients presenting with low proteinuria with moderately preserved eGFR. Conclusions: There are few national registries of diabetic nephropathy to evaluate prognosis in Japan. Future analysis of the JDNCS will provide clinical insights into the epidemiology and renal and cardiovascular outcomes of type 2 diabetic patients in Japan.
AB - Background: Diabetic nephropathy, leading to end-stage renal disease, has a considerable impact on public health and the social economy. However, there are few national registries of diabetic nephropathy in Japan. The aims of this prospective cohort study are to obtain clinical data and urine samples for revising the clinical staging of diabetic nephropathy, and developing new diagnostic markers for early diabetic nephropathy. Methods: The Japanese Society of Nephrology established a nationwide, web-based, and prospective registry system. On the system, there are two basic registries; the Japan Renal Biopsy Registry (JRBR), and the Japan Kidney Disease Registry (JKDR). In addition to the two basic registries, we established a new prospective registry to the system; the Japan Diabetic Nephropathy Cohort Study (JDNCS), which collected physical and laboratory data. Results: We analyzed the data of 321 participants (106 female, 215 male; average age 65 years) in the JDNCS. Systolic and diastolic blood pressure was 130.1 and 72.3 mmHg, respectively. Median estimated glomerular filtration rate (eGFR) was 33.3 ml/min/1.73 m2. Proteinuria was 1.8 g/gCr, and serum levels of albumin were 3.6 g/dl. The majority of the JDNCS patients presented with preserved eGFR and low albuminuria or low eGFR and advanced proteinuria. In the JRBR and JKDR registries, 484 and 125 participants, respectively, were enrolled as having diabetes mellitus. In comparison with the JRBR and JKDR registries, the JDNCS was characterized by diabetic patients presenting with low proteinuria with moderately preserved eGFR. Conclusions: There are few national registries of diabetic nephropathy to evaluate prognosis in Japan. Future analysis of the JDNCS will provide clinical insights into the epidemiology and renal and cardiovascular outcomes of type 2 diabetic patients in Japan.
KW - Cohort study
KW - Diabetic nephropathy
KW - Estimated glomerular filtration rate
KW - Japan Diabetic Nephropathy Cohort Study
KW - Japan Kidney Disease Registry
KW - Japan Renal Biopsy Registry
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U2 - 10.1007/s10157-013-0778-8
DO - 10.1007/s10157-013-0778-8
M3 - Article
C2 - 23446518
AN - SCOPUS:84891486926
VL - 17
SP - 819
EP - 826
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
SN - 1342-1751
IS - 6
ER -