Abstract
Objective: We propose a method that allows the separation of epileptiform discharges (EDs) from the EEG background, including the ED's waveform and spatial distribution. The method even allows to separate a spike in two components occurring at approximately the same time but having different waveforms and spatial distributions. Methods: The separation employs independent component analysis (ICA) and is not based on any assumption regarding generator model. A simulation study was performed by generating ten EEG data matrices by computer: each matrix included real background activity from a normal subject to which was added an array of simulated unaveraged EDs. Each discharge was a summation of two transients having slightly different potential field distributions and small jitters in time and amplitude. Real EEG data were also obtained from three epileptic patients. Results: Through ICA, we could isolate the two epileptiform transients in every simulation matrix, and the retrieved transients were almost identical as the originals, especially in their spatial distributions. Two epileptic components were isolated by ICA in all patients. Each estimated epileptic component had a consistent time course. Conclusion: ICA appears promising for the separation of unaveraged spikes from the EEG background and their decomposition in independent spatio-temporal components.
| Original language | English |
|---|---|
| Pages (from-to) | 1755-1763 |
| Number of pages | 9 |
| Journal | Clinical Neurophysiology |
| Volume | 110 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1 1999 |
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Keywords
- EEG
- Epileptiform discharge
- Independent component analysis
- Principal component analysis
ASJC Scopus subject areas
- Clinical Neurology
- Radiology Nuclear Medicine and imaging
- Neurology
- Sensory Systems
- Physiology (medical)
Cite this
Isolation of epileptiform discharges from unaveraged EEG by independent component analysis. / Kobayashi, Katsuhiro; James, C. J.; Nakahori, T.; Akiyama, Tomoyuki; Gotman, J.
In: Clinical Neurophysiology, Vol. 110, No. 10, 01.10.1999, p. 1755-1763.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isolation of epileptiform discharges from unaveraged EEG by independent component analysis
AU - Kobayashi, Katsuhiro
AU - James, C. J.
AU - Nakahori, T.
AU - Akiyama, Tomoyuki
AU - Gotman, J.
PY - 1999/10/1
Y1 - 1999/10/1
N2 - Objective: We propose a method that allows the separation of epileptiform discharges (EDs) from the EEG background, including the ED's waveform and spatial distribution. The method even allows to separate a spike in two components occurring at approximately the same time but having different waveforms and spatial distributions. Methods: The separation employs independent component analysis (ICA) and is not based on any assumption regarding generator model. A simulation study was performed by generating ten EEG data matrices by computer: each matrix included real background activity from a normal subject to which was added an array of simulated unaveraged EDs. Each discharge was a summation of two transients having slightly different potential field distributions and small jitters in time and amplitude. Real EEG data were also obtained from three epileptic patients. Results: Through ICA, we could isolate the two epileptiform transients in every simulation matrix, and the retrieved transients were almost identical as the originals, especially in their spatial distributions. Two epileptic components were isolated by ICA in all patients. Each estimated epileptic component had a consistent time course. Conclusion: ICA appears promising for the separation of unaveraged spikes from the EEG background and their decomposition in independent spatio-temporal components.
AB - Objective: We propose a method that allows the separation of epileptiform discharges (EDs) from the EEG background, including the ED's waveform and spatial distribution. The method even allows to separate a spike in two components occurring at approximately the same time but having different waveforms and spatial distributions. Methods: The separation employs independent component analysis (ICA) and is not based on any assumption regarding generator model. A simulation study was performed by generating ten EEG data matrices by computer: each matrix included real background activity from a normal subject to which was added an array of simulated unaveraged EDs. Each discharge was a summation of two transients having slightly different potential field distributions and small jitters in time and amplitude. Real EEG data were also obtained from three epileptic patients. Results: Through ICA, we could isolate the two epileptiform transients in every simulation matrix, and the retrieved transients were almost identical as the originals, especially in their spatial distributions. Two epileptic components were isolated by ICA in all patients. Each estimated epileptic component had a consistent time course. Conclusion: ICA appears promising for the separation of unaveraged spikes from the EEG background and their decomposition in independent spatio-temporal components.
KW - EEG
KW - Epileptiform discharge
KW - Independent component analysis
KW - Principal component analysis
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UR - http://www.scopus.com/inward/citedby.url?scp=0032887366&partnerID=8YFLogxK
U2 - 10.1016/S1388-2457(99)00134-0
DO - 10.1016/S1388-2457(99)00134-0
M3 - Article
C2 - 10574290
AN - SCOPUS:0032887366
VL - 110
SP - 1755
EP - 1763
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 10
ER -