Isolation of canine coronary sinus musculature from the atria by radiofrequency catheter ablation prevents induction of atrial fibrillation

Hiroshi Morita, Douglas P. Zipes, Shiho T. Morita, Jiashin Wu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The junction between the coronary sinus (CS) musculature and both atria contributes to initiation of atrial tachyarrhythmias. The current study investigated the effects of CS isolation from the atria by radiofrequency catheter ablation on the induction and maintenance of atrial fibrillation (AF). Methods and Results: Using an optical mapping system, we mapped action potentials at 256 surface sites in 17 isolated and arterially perfused canine atrial tissues containing the entire musculature of the CS, right atrial septum, posterior left atrium, left inferior pulmonary vein, and vein of Marshal. Rapid pacing from each site before and after addition of acetylcholine (0.5 μmol/L) was applied to induce AF. Epicardial radiofrequency catheter ablation at CS-atrial junctions isolated the CS from the atria. Rapid pacing induced sustained AF in all tissues after acetylcholine. Microreentry within the CS drove AF in 88% of preparations. Reentries associated with the vein of Marshall (29%), CS-atrial junctions (53%), right atrium (65%), and pulmonary vein (76%) (frequently with 2-4 simultaneous circuits) were additional drivers of AF. Radiofrequency catheter ablation eliminated AF in 13 tissues before acetylcholine (P

Original languageEnglish
Pages (from-to)1181-1188
Number of pages8
JournalCirculation: Arrhythmia and Electrophysiology
Volume7
Issue number6
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Catheter Ablation
Coronary Sinus
Atrial Fibrillation
Canidae
Acetylcholine
Pulmonary Veins
Heart Atria
Veins
Atrial Septum
Optical Devices
Tachycardia
Action Potentials
Maintenance

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Coronary sinus
  • Optical Vm mapping

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

Cite this

Isolation of canine coronary sinus musculature from the atria by radiofrequency catheter ablation prevents induction of atrial fibrillation. / Morita, Hiroshi; Zipes, Douglas P.; Morita, Shiho T.; Wu, Jiashin.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 7, No. 6, 01.12.2014, p. 1181-1188.

Research output: Contribution to journalArticle

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