Isolation and characterization of the mouse corticotropin-β-lipotropin precursor gene and a related pseudogene

Mitsue Notake, Takamasa Tobimatsu, Yumiko Watanabe, Hideo Takahashi, Masayoshi Mishina, Shosaku Numa

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Abstract

Two mouse genomic DNA sequences homologous with human corticotropin-β-lipotropin precursor gene sequences have been cloned. One of them represents the functional corticotropin-β-lipotropin precursor gene, which exhibits a structural organization similar to those of its bovine and human counterparts. The other represents a pseudogene that corresponds to the functional mouse gene sequence encoding the carboxy-terminal 143 amino acid residues (including corticotropin and β-lipotropin) and the 3′-untranslated region.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalFEBS Letters
Volume156
Issue number1
DOIs
Publication statusPublished - May 30 1983

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Keywords

  • DNA sequence
  • Direct repeat
  • Exon/intron
  • Mouse corticotropin-β-lipotropin precursor gene
  • Pseudogene
  • Recombinant DNA

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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