Isoflurane induces transient impairment of retention of spatial working memory in rats

Masaaki Tanino, Motomu Kobayashi, Toshihiro Sasaki, Ken Takata, Yoshimasa Takeda, Satoshi Mizobuchi, Kiyoshi Morita, Taku Nagai, Hiroshi Morimatsu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane- induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalActa Medica Okayama
Volume70
Issue number6
Publication statusPublished - 2016

Fingerprint

Isoflurane
Short-Term Memory
Rats
Anesthesia
Data storage equipment
Animal Behavior
General Anesthesia
Surgery
Cognition
Animals
Spatial Memory
Retention (Psychology)
Recovery

Keywords

  • Delayed spatial win-shift task
  • Isoflurane
  • Postoperative cognitive dysfunction
  • Retention
  • Spatial working memory

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Isoflurane induces transient impairment of retention of spatial working memory in rats. / Tanino, Masaaki; Kobayashi, Motomu; Sasaki, Toshihiro; Takata, Ken; Takeda, Yoshimasa; Mizobuchi, Satoshi; Morita, Kiyoshi; Nagai, Taku; Morimatsu, Hiroshi.

In: Acta Medica Okayama, Vol. 70, No. 6, 2016, p. 455-460.

Research output: Contribution to journalArticle

Tanino, M, Kobayashi, M, Sasaki, T, Takata, K, Takeda, Y, Mizobuchi, S, Morita, K, Nagai, T & Morimatsu, H 2016, 'Isoflurane induces transient impairment of retention of spatial working memory in rats', Acta Medica Okayama, vol. 70, no. 6, pp. 455-460.
Tanino, Masaaki ; Kobayashi, Motomu ; Sasaki, Toshihiro ; Takata, Ken ; Takeda, Yoshimasa ; Mizobuchi, Satoshi ; Morita, Kiyoshi ; Nagai, Taku ; Morimatsu, Hiroshi. / Isoflurane induces transient impairment of retention of spatial working memory in rats. In: Acta Medica Okayama. 2016 ; Vol. 70, No. 6. pp. 455-460.
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