Ishigadine A, a new canthin-6-one alkaloid from an Okinawan marine sponge Hyrtios sp.

Hideaki Takahashi, Shin ichiro Kurimoto, Jun'ichi Kobayashi, Takaaki Kubota

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A new indole alkaloid with the canthin-6-one skeleton, ishigadine A, has been isolated from an Okinawan marine sponge Hyrtios sp. The structure of ishigadine A was elucidated on the basis of spectroscopic analyses. Ishigadine A is a new canthin-6-one alkaloid possessing a hydroxy group, a 1,3-dimethyl-4-methylthioimidazolium, and a 1-propylguanidine. Ishigadine A is the third canthin-6-one alkaloid from sponges. Ishigadine A might be generated from L-arginine, L-histidine, and L-tryptophan. Ishigadine A exhibited moderate cytotoxicity against L1210 murine leukemia cells.

Original languageEnglish
Pages (from-to)4500-4502
Number of pages3
JournalTetrahedron Letters
Volume59
Issue number51
DOIs
Publication statusPublished - Dec 19 2018
Externally publishedYes

Keywords

  • Canthin-6-one
  • Cytotoxicity
  • Hyrtios sp.
  • Ishigadine A
  • Marine sponge

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Ishigadine A, a new canthin-6-one alkaloid from an Okinawan marine sponge Hyrtios sp.'. Together they form a unique fingerprint.

Cite this