Is serotonin involved in hypothermic effect and its tolerance development of Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol in the mouse?

K. Watanabe, I. Yamamoto, S. Narimatsu, H. Yoshimura

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Abstract

The role of serotonin in the hypothermic effect and its tolerance development of Δ8-tetrahydrocannabinol (Δ8-THC) and 11-hydroxy-Δ8-tetrahydrocannabinol (11-OH-Δ8-THC) was investigated in mice. Pretreatment with p-chorophenylalanine (300 mg/kg i.p. for 2 days and 100 mg/kg i.p. for 1 day) or 5,6-dihydroxytryptamine (50 μg/mouse i.c.v) did not block the hypothermic effect of both cannabinoids (5 mg/kg i.v.). Cinanserine, an antagonist for serotonin receptor, was also unable to block the effect of the cannabinoids. On the other hand, both cannabinoids-tolerant mice (5 mg/kg/day i.v. for 3 days) showed partially cross-tolerance to the hypothermic effect of serotonin (160 μg/mouse i.c.v. or 10 mg/kg i.v.). Moreover, daily administration of cinanserine (10 mg/kg i.p.) inhibited partially tolerance development to the hypothermic effect of Δ8-TH and 11-OH-Δ8-THC. These results suggest that serotonin is not primarily responsible for the hypothermic effect of Δ8-THC and 11-OH-Δ8-THC but may have some role in the tolerance development to the hypothermic effect of these cannabinoids in mice.

Original languageEnglish
Pages (from-to)89-101
Number of pages13
JournalResearch Communications in Substances of Abuse
Volume5
Issue number2
Publication statusPublished - Jan 1 1984

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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