Is interleukin-1α a luteotrophic or luteolytic agent in cattle?

Magdalena Majewska, Izabela Woclawek-Potocka, Mamadou M. Bah, Joanna Hapunik, Katarzyna K. Piotrowska, Yukari Tasaki, Tomas J. Acosta, Kiyoshi Okuda, Dariusz J. Skarzynski

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cytokines are thought to regulate prostaglandin (PG) secretion in the bovine endometrium. However, there is no consensus about the role of interleukin-1α (IL1A) on PG secretion. The objective of this study was to examine the influence of IL1A on basal and interferon-τ (IFNT)-regulated PG in vitro secretion, as well its effects on PG secretion, progesterone (P 4) output, and corpus luteum (CL) in vivo lifespan. Explants of bovine endometrium (days 16-17 of the estrous cycle or early pregnancy) were stimulated with IL1A (10 ng/ml), IFNT (30 ng/ml), or IL1A combined with IFN. IL1A alone strongly stimulated luteotrophic PGE2 secretion by endometrial tissues of both pregnant and nonpregnant cows. IL1A also stimulated luteolytic PGF output in the late luteal phase. IFNT augmented the stimulatory effect of IL1A on PGE2 secretion. In an in vivo experiment, saline or IL1A at different doses (0.001-10 μg/per animal) was applied to the uterine lumen on day 16 of the cycle. Only the highest dose of IL1A caused a temporal increase in PGF secretion, while it had no effect on P4 secretion or CL lifespan. Application of 0.1 and 1 μg IL1A stimulated P4 and PGE2 output and prolonged the CL lifespan. Although IL1A may stimulate in vitro luteolytic PGF secretion during the estrous cycle, it only acts as a luteotrophic factor in vivo. IL1A increased luteotrophic PGE2 and P4 output, inhibiting spontaneous luteolysis. These luteotrophic effects may result in appropriate luteal development and function in cows during the estrous cycle and early pregnancy.

Original languageEnglish
Pages (from-to)665-672
Number of pages8
JournalReproduction
Volume139
Issue number3
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Luteolytic Agents
Corpus Luteum
Interleukin-1
Dinoprostone
Prostaglandins
Dinoprost
Estrous Cycle
Endometrium
Luteolysis
Pregnancy
Luteal Phase
Interferons
Progesterone
Cytokines

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Embryology
  • Endocrinology
  • Cell Biology
  • Medicine(all)

Cite this

Majewska, M., Woclawek-Potocka, I., Bah, M. M., Hapunik, J., Piotrowska, K. K., Tasaki, Y., ... Skarzynski, D. J. (2010). Is interleukin-1α a luteotrophic or luteolytic agent in cattle? Reproduction, 139(3), 665-672. https://doi.org/10.1530/REP-09-0328

Is interleukin-1α a luteotrophic or luteolytic agent in cattle? / Majewska, Magdalena; Woclawek-Potocka, Izabela; Bah, Mamadou M.; Hapunik, Joanna; Piotrowska, Katarzyna K.; Tasaki, Yukari; Acosta, Tomas J.; Okuda, Kiyoshi; Skarzynski, Dariusz J.

In: Reproduction, Vol. 139, No. 3, 03.2010, p. 665-672.

Research output: Contribution to journalArticle

Majewska, M, Woclawek-Potocka, I, Bah, MM, Hapunik, J, Piotrowska, KK, Tasaki, Y, Acosta, TJ, Okuda, K & Skarzynski, DJ 2010, 'Is interleukin-1α a luteotrophic or luteolytic agent in cattle?', Reproduction, vol. 139, no. 3, pp. 665-672. https://doi.org/10.1530/REP-09-0328
Majewska M, Woclawek-Potocka I, Bah MM, Hapunik J, Piotrowska KK, Tasaki Y et al. Is interleukin-1α a luteotrophic or luteolytic agent in cattle? Reproduction. 2010 Mar;139(3):665-672. https://doi.org/10.1530/REP-09-0328
Majewska, Magdalena ; Woclawek-Potocka, Izabela ; Bah, Mamadou M. ; Hapunik, Joanna ; Piotrowska, Katarzyna K. ; Tasaki, Yukari ; Acosta, Tomas J. ; Okuda, Kiyoshi ; Skarzynski, Dariusz J. / Is interleukin-1α a luteotrophic or luteolytic agent in cattle?. In: Reproduction. 2010 ; Vol. 139, No. 3. pp. 665-672.
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