Is atherosclerosis an autoimmune disease?

Eiji Matsuura, Fabiola Atzeni, Piercarlo Sarzi-Puttini, Maurizio Turiel, Luis R. Lopez, Michael T. Nurmohamed

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Immunologic research into pathogenic mechanisms operating in autoimmune-mediated atherosclerosis initially focused on adaptive immunity. Current interest is directed to more basic inflammatory mechanisms. Chronic inflammation (innate immunity-associated) may trigger initial events that can lead to atherosclerotic cardiovascular disease. This chronic inflammation may start early in life and be perpetuated by classic atherosclerosis risk factors. Lipid peroxidation of low-density lipoprotein seems to be a key event in the initiation and progression of atherosclerosis. Oxidized low-density lipoprotein triggers inflammatory and immunogenic events that promote endothelial dysfunction and the synthesis and secretion of pro-inflammatory cytokines, leading to an autoimmune response capable of accelerating the intracellular accumulation of lipids within atherosclerotic plaques. Oxidized low-density lipoprotein binds β2-glycoprotein I to form circulating complexes found in both autoimmune and non-autoimmune atherosclerosis. It is likely that β2-glycoprotein I and/or these complexes contribute to early atherogenesis by stimulating pro-inflammatory innate immunity through endogenous sensors and inflammasome/interleukin-1 pathways. We discuss the chronic inflammatory (innate) and autoimmune (adaptive) responses operating in atherosclerosis to discern the role of autoimmunity in atherosclerotic cardiovascular disease.

Original languageEnglish
Article number47
JournalBMC Medicine
Volume12
Issue number1
DOIs
Publication statusPublished - Mar 18 2014

Fingerprint

Autoimmune Diseases
Atherosclerosis
Autoimmunity
LDL Lipoproteins
Innate Immunity
Glycoproteins
Cardiovascular Diseases
Inflammasomes
Inflammation
Adaptive Immunity
Atherosclerotic Plaques
Interleukin-1
Lipid Peroxidation
Cytokines
Lipids
Research
oxidized low density lipoprotein

Keywords

  • Atherosclerosis
  • Auto-inflammatory disease
  • Autoimmunity
  • Inflammasome
  • Innate immunity
  • Oxidized LDL
  • β2-glycoprotein I

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Matsuura, E., Atzeni, F., Sarzi-Puttini, P., Turiel, M., Lopez, L. R., & Nurmohamed, M. T. (2014). Is atherosclerosis an autoimmune disease? BMC Medicine, 12(1), [47]. https://doi.org/10.1186/1741-7015-12-47

Is atherosclerosis an autoimmune disease? / Matsuura, Eiji; Atzeni, Fabiola; Sarzi-Puttini, Piercarlo; Turiel, Maurizio; Lopez, Luis R.; Nurmohamed, Michael T.

In: BMC Medicine, Vol. 12, No. 1, 47, 18.03.2014.

Research output: Contribution to journalArticle

Matsuura, E, Atzeni, F, Sarzi-Puttini, P, Turiel, M, Lopez, LR & Nurmohamed, MT 2014, 'Is atherosclerosis an autoimmune disease?', BMC Medicine, vol. 12, no. 1, 47. https://doi.org/10.1186/1741-7015-12-47
Matsuura E, Atzeni F, Sarzi-Puttini P, Turiel M, Lopez LR, Nurmohamed MT. Is atherosclerosis an autoimmune disease? BMC Medicine. 2014 Mar 18;12(1). 47. https://doi.org/10.1186/1741-7015-12-47
Matsuura, Eiji ; Atzeni, Fabiola ; Sarzi-Puttini, Piercarlo ; Turiel, Maurizio ; Lopez, Luis R. ; Nurmohamed, Michael T. / Is atherosclerosis an autoimmune disease?. In: BMC Medicine. 2014 ; Vol. 12, No. 1.
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