Abstract
β-1,3-Dicarbonyl aldehydes were synthesized by iron-catalyzed oxidative reactions between 1,3-dicarbonyl compounds and two molecules of tertiary amines in the presence of tert-butyl hydroperoxide (TBHP). α,β-Unsaturated aldehydes generated by tertiary amine oxidation in situ act as key intermediates under mild reaction conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 6272-6275 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 13 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - Dec 2 2011 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Liu, W., Liu, J., Ogawa, D., Nishihara, Y., Guo, X., & Li, Z. (2011). Iron-catalyzed oxidation of tertiary amines: Synthesis of β-1,3-dicarbonyl aldehydes by three-component C-C couplings. Organic Letters, 13(23), 6272-6275. https://doi.org/10.1021/ol202749x