Iron-catalyzed ortho -allylation of aromatic carboxamides with allyl ethers

Sobi Asako, Laurean Ilies, Eiichi Nakamura

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Arenes possessing an N-(quinolin-8-yl)amide directing group are ortho-allylated with allyl phenyl ether in the presence of an iron/diphosphine catalyst and an organometallic base at 50-70 C. The reaction proceeds via fast iron-catalyzed C-H activation, followed by reaction of the resulting iron intermediate with the allyl ether in γ-selective fashion.

Original languageEnglish
Pages (from-to)17755-17757
Number of pages3
JournalJournal of the American Chemical Society
Volume135
Issue number47
DOIs
Publication statusPublished - Nov 27 2013

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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