TY - JOUR
T1 - Irnmunohistochemical study of glutathione S-transferase (GST-π) on hepatocellular carcinoma
AU - Ogino, Keiki
AU - Sakaida, Isao
AU - Oka, Shinji
AU - Murakami, Hujio
AU - Hino, Keisuke
AU - Sanuki, Kazutoshi
AU - Shingai, Yasushi
AU - Nawata, Hiroshi
AU - Kado, Yuji
AU - Yasunaga, Mitsuru
AU - Ezaki, Takaro
AU - Ando, Keijiro
AU - Okita, Kiwamu
AU - Takemoto, Tadayoshi
PY - 1986
Y1 - 1986
N2 - Anionic form of glutathione S-transferase (Gst-π)was purified in apparent homogenity from human placenta. The molecular weight of GST-π was 21,000 by SDS-polyacrylamide gel electrophoresis and isoelectric point was 4.5 by analytical electrophocussing gel electrophoresis. According to Ouchtrlony’s method, antigenicity of GSY-π was identical with anionic GST from hepatocellular carcinoma and kidney. Immunohistochemical localization of GST-n in 30 cases of hepatocellular carcinoma revealed that positive staining was shown in 50% cases compared to Edmondson’s grade I or II. It was interesting that hepatocytes around cancer tissue, not found out atypism, were stained intensively sometimes. Therefore, it is suggested that Gst-πmay be tumor marker for hepatocellular carcinoma. However, the investigation of GST-π rich hepatocytes around cancer tissue is necessary in connection with pre-cancerous lesion.
AB - Anionic form of glutathione S-transferase (Gst-π)was purified in apparent homogenity from human placenta. The molecular weight of GST-π was 21,000 by SDS-polyacrylamide gel electrophoresis and isoelectric point was 4.5 by analytical electrophocussing gel electrophoresis. According to Ouchtrlony’s method, antigenicity of GSY-π was identical with anionic GST from hepatocellular carcinoma and kidney. Immunohistochemical localization of GST-n in 30 cases of hepatocellular carcinoma revealed that positive staining was shown in 50% cases compared to Edmondson’s grade I or II. It was interesting that hepatocytes around cancer tissue, not found out atypism, were stained intensively sometimes. Therefore, it is suggested that Gst-πmay be tumor marker for hepatocellular carcinoma. However, the investigation of GST-π rich hepatocytes around cancer tissue is necessary in connection with pre-cancerous lesion.
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U2 - 10.2957/kanzo.27.1439
DO - 10.2957/kanzo.27.1439
M3 - Article
AN - SCOPUS:85004500516
VL - 27
SP - 1439
EP - 1443
JO - Acta Hepatologica Japonica
JF - Acta Hepatologica Japonica
SN - 0451-4203
IS - 10
ER -
