Iridium(III)-catalyzed branch-selective Câ'H alkenylation of aniline derivatives with alkenes

Shrikant M. Khake, Ken Yamazaki, Yusuke Ano, Naoto Chatani

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The branch-selective Câ'H alkenylation with alkenes using an iridium catalyst is reported. The Ir(III)-catalyzed reaction of aniline derivatives that contain a pyrimidine-directing group with vinylsilanes and terminal aliphatic alkenes results in branch-selective Câ'H alkenylation. The reaction provides a broad substrate scope for aniline derivatives, and a variety of functional groups are tolerated. Density functional theory calculations were performed in an attempt to understand the origin of the branch selectivity.

Original languageEnglish
Pages (from-to)5463-5471
Number of pages9
JournalACS Catalysis
Volume11
Issue number9
DOIs
Publication statusPublished - May 7 2021
Externally publishedYes

Keywords

  • Branch selectivity
  • Câ'H alkenylation
  • CâH activation
  • Iridium
  • Vinylsilane

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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