Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)

Youji Kitamura, Masaki Mifune, Tsutomu Takatsuki, Toshinobu Iwasaki, Mayu Kawamoto, Akimasa Iwado, Masahiko Chikuma, Yutaka Saito

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To develop a solid catalyst which can be a model of catechol oxidase and/or catecholamine monoamine oxidase, the ion-exchange resins modified with metal-tetrakis(4-sulfophenyl)porphine (M-TSPP wherein M is Mn3+, Co3+, Fe3+ or Cu2+) were examined for a catalytic activity in the oxidative reaction of epinephrine (adrenaline, Ad). Among M-TSPP-modified resins (M-TSPPrs), Mn-TSPPr exhibited the strongest catalytic activity in the oxidation of Ad with O2 in the air to adrenochrome and adrenolutin. Mn-TSPP had little catalytic activity in an aqueous solution of Ad. The optimum conditions for the oxidation reaction catalyzed by Mn-TSPPr were determined. Oxidation of catecholamines and related compounds thereof were conducted under the optimum conditions thus determined, which revealed that Mn-TSPPr only catalyzes oxidation of catecholamines.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalCatalysis Communications
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Ion Exchange Resins
Ion exchange resins
Porphyrins
Catalysis
Epinephrine
Metals
Catecholamines
Catalyst activity
Oxidation
Adrenochrome
Catechol Oxidase
Monoamine Oxidase
Resins
Catalysts
Air
tetraphenylporphine sulfonate
Oxidoreductases

Keywords

  • Catalysis
  • Catecholamine
  • Epinephrine
  • Immobilization
  • Metal-porphyrin
  • Mimetic
  • Oxidation

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology

Cite this

Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline). / Kitamura, Youji; Mifune, Masaki; Takatsuki, Tsutomu; Iwasaki, Toshinobu; Kawamoto, Mayu; Iwado, Akimasa; Chikuma, Masahiko; Saito, Yutaka.

In: Catalysis Communications, Vol. 9, No. 2, 02.2008, p. 224-228.

Research output: Contribution to journalArticle

Kitamura, Y, Mifune, M, Takatsuki, T, Iwasaki, T, Kawamoto, M, Iwado, A, Chikuma, M & Saito, Y 2008, 'Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)', Catalysis Communications, vol. 9, no. 2, pp. 224-228. https://doi.org/10.1016/j.catcom.2007.06.005
Kitamura, Youji ; Mifune, Masaki ; Takatsuki, Tsutomu ; Iwasaki, Toshinobu ; Kawamoto, Mayu ; Iwado, Akimasa ; Chikuma, Masahiko ; Saito, Yutaka. / Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline). In: Catalysis Communications. 2008 ; Vol. 9, No. 2. pp. 224-228.
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AU - Iwasaki, Toshinobu

AU - Kawamoto, Mayu

AU - Iwado, Akimasa

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AB - To develop a solid catalyst which can be a model of catechol oxidase and/or catecholamine monoamine oxidase, the ion-exchange resins modified with metal-tetrakis(4-sulfophenyl)porphine (M-TSPP wherein M is Mn3+, Co3+, Fe3+ or Cu2+) were examined for a catalytic activity in the oxidative reaction of epinephrine (adrenaline, Ad). Among M-TSPP-modified resins (M-TSPPrs), Mn-TSPPr exhibited the strongest catalytic activity in the oxidation of Ad with O2 in the air to adrenochrome and adrenolutin. Mn-TSPP had little catalytic activity in an aqueous solution of Ad. The optimum conditions for the oxidation reaction catalyzed by Mn-TSPPr were determined. Oxidation of catecholamines and related compounds thereof were conducted under the optimum conditions thus determined, which revealed that Mn-TSPPr only catalyzes oxidation of catecholamines.

KW - Catalysis

KW - Catecholamine

KW - Epinephrine

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KW - Metal-porphyrin

KW - Mimetic

KW - Oxidation

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