Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)

Youji Kitamura, Masaki Mifune, Tsutomu Takatsuki, Toshinobu Iwasaki, Mayu Kawamoto, Akimasa Iwado, Masahiko Chikuma, Yutaka Saito

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To develop a solid catalyst which can be a model of catechol oxidase and/or catecholamine monoamine oxidase, the ion-exchange resins modified with metal-tetrakis(4-sulfophenyl)porphine (M-TSPP wherein M is Mn3+, Co3+, Fe3+ or Cu2+) were examined for a catalytic activity in the oxidative reaction of epinephrine (adrenaline, Ad). Among M-TSPP-modified resins (M-TSPPrs), Mn-TSPPr exhibited the strongest catalytic activity in the oxidation of Ad with O2 in the air to adrenochrome and adrenolutin. Mn-TSPP had little catalytic activity in an aqueous solution of Ad. The optimum conditions for the oxidation reaction catalyzed by Mn-TSPPr were determined. Oxidation of catecholamines and related compounds thereof were conducted under the optimum conditions thus determined, which revealed that Mn-TSPPr only catalyzes oxidation of catecholamines.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalCatalysis Communications
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Catalysis
  • Catecholamine
  • Epinephrine
  • Immobilization
  • Metal-porphyrin
  • Mimetic
  • Oxidation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Process Chemistry and Technology

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