Inwardly rectifying K+ currents in intermediate cells in the cochlea of gerbils: A possible contribution to the endocochlear potential

Shunji Takeuchi, Motonori Ando

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The stria vascularis in the cochlea generates the endocochlear potential (EP) and secretes K+-rich endolymph; both are indispensable for normal sound transduction by hair cells. K+ conductance in the intermediate cell, one of the several types of cells constituting the stria vascularis, was investigated by the whole-cell patch-clamp technique. Inwardly-rectifying K+ (K(ir)) currents were the major currents observed. The currents were inhibited dose-dependently by Ba2+, quinine, verapamil and Cs+, but not by tetraethylammonium (20 mM), 4-aminopyridine (5 mM) or Cd2+ (1 mM). The similarity between the effect of inhibitors on Kit currents and on the EP (Takeuchi et al., Hearing Res., 101 (1996) 181-185) suggests a direct contribution of the K(ir) conductance to the generation of the EP.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalNeuroscience Letters
Issue number2-3
Publication statusPublished - May 15 1998



  • 4-aminopyridine
  • K(ir) channel
  • Melanocyte
  • Quinine
  • Stria vascularis
  • Tetraethylammonium
  • Verapamil

ASJC Scopus subject areas

  • Neuroscience(all)

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