Involvement of vulnibactin and exocellular protease in utilization of transferrin- and lactoferrin-bound iron by Vibrio vulnificus

Noriyuki Okujo, Toshihito Akiyama, Shin-ichi Miyoshi, Sumio Shinoda, Shigeo Yamamoto

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In vitro growth experiments were conducted to evaluate the ability of vulnibactin, a siderophore produced by Vibrio vulnificus, to sequester transferrin- or lactoferrin-bound iron for growth. Comparative studies with the strain producing vulnibactin and its exocellular protease-deficient mutant revealed the involvement of the protease in addition to vulnibactin in effective utilization of iron ion (Fe3+) bound to transferrin and lactoferrin. It appears that the protease causes cleavage of these proteins, thereby making bound iron more accessible to vulnibactin.

Original languageEnglish
Pages (from-to)595-598
Number of pages4
JournalMicrobiology and Immunology
Issue number8
Publication statusPublished - 1996



  • Exocellular protease
  • Iron assimilation
  • Siderophore
  • Vibrio vulnificus

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Microbiology

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