Involvement of vulnibactin and exocellular protease in utilization of transferrin- and lactoferrin-bound iron by Vibrio vulnificus

Noriyuki Okujo, Toshihito Akiyama, Shin Ichi Miyoshi, Sumio Shinoda, Shigeo Yamamoto

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

In vitro growth experiments were conducted to evaluate the ability of vulnibactin, a siderophore produced by Vibrio vulnificus, to sequester transferrin- or lactoferrin-bound iron for growth. Comparative studies with the strain producing vulnibactin and its exocellular protease-deficient mutant revealed the involvement of the protease in addition to vulnibactin in effective utilization of iron ion (Fe3+) bound to transferrin and lactoferrin. It appears that the protease causes cleavage of these proteins, thereby making bound iron more accessible to vulnibactin.

Original languageEnglish
Pages (from-to)595-598
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume40
Issue number8
DOIs
Publication statusPublished - 1996

Keywords

  • Exocellular protease
  • Iron assimilation
  • Siderophore
  • Vibrio vulnificus

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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