Involvement of tumor necrosis factor-α and interleukin-8 in antigen-induced arthritis of the rabbit temporomandibular joint

Miho Sukedai, Kazuhiro Tominaga, Manabu Habu, Akihiro Matsukawa, Tatsuji Nishihara, Jinichi Fukuda

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

BACKGROUND: In temporomandibular joint (TMJ) arthritis, knowledge is limited about the source of the inflammatory mediators. The aim of this study was to investigate the immunohistochemical role of tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) in the development of the antigen-induced arthritis of the rabbit TMJ. METHODS: Unilateral TMJ arthritis was induced in 28 adult rabbits. From 6 h to 6 weeks after induction of arthritis, the topology of TNF-α and IL-8 was observed. RESULTS: Positive reaction for TNF-α of synovial cells was observed within 3 days after induction and at 3 weeks after induction. TNF-α positive vascular endothelial cells and chondrocytes were identified throughout the observation period. IL-8 was detected only during the acute stage. CONCLUSIONS: The cytokines TNF-α and IL-8 were observed in specific cells depending on the stage. TNF-α was particularly related with angiogenesis and cartilage destruction and IL-8 was involved in the acute stage of inflammation.

Original languageEnglish
Pages (from-to)102-110
Number of pages9
JournalJournal of Oral Pathology and Medicine
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2004
Externally publishedYes

Fingerprint

Temporomandibular Joint
Interleukin-8
Arthritis
Tumor Necrosis Factor-alpha
Rabbits
Antigens
Chondrocytes
Cartilage
Endothelial Cells
Observation
Cytokines
Inflammation

Keywords

  • Antigen-induced arthritis
  • Immunohistochemistry
  • Interleukin-8
  • Rabbit
  • Temporomandibular joint
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Involvement of tumor necrosis factor-α and interleukin-8 in antigen-induced arthritis of the rabbit temporomandibular joint. / Sukedai, Miho; Tominaga, Kazuhiro; Habu, Manabu; Matsukawa, Akihiro; Nishihara, Tatsuji; Fukuda, Jinichi.

In: Journal of Oral Pathology and Medicine, Vol. 33, No. 2, 02.2004, p. 102-110.

Research output: Contribution to journalArticle

Sukedai, Miho ; Tominaga, Kazuhiro ; Habu, Manabu ; Matsukawa, Akihiro ; Nishihara, Tatsuji ; Fukuda, Jinichi. / Involvement of tumor necrosis factor-α and interleukin-8 in antigen-induced arthritis of the rabbit temporomandibular joint. In: Journal of Oral Pathology and Medicine. 2004 ; Vol. 33, No. 2. pp. 102-110.
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AU - Nishihara, Tatsuji

AU - Fukuda, Jinichi

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AB - BACKGROUND: In temporomandibular joint (TMJ) arthritis, knowledge is limited about the source of the inflammatory mediators. The aim of this study was to investigate the immunohistochemical role of tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) in the development of the antigen-induced arthritis of the rabbit TMJ. METHODS: Unilateral TMJ arthritis was induced in 28 adult rabbits. From 6 h to 6 weeks after induction of arthritis, the topology of TNF-α and IL-8 was observed. RESULTS: Positive reaction for TNF-α of synovial cells was observed within 3 days after induction and at 3 weeks after induction. TNF-α positive vascular endothelial cells and chondrocytes were identified throughout the observation period. IL-8 was detected only during the acute stage. CONCLUSIONS: The cytokines TNF-α and IL-8 were observed in specific cells depending on the stage. TNF-α was particularly related with angiogenesis and cartilage destruction and IL-8 was involved in the acute stage of inflammation.

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