Involvement of tumor necrosis factor-α and interleukin-8 in antigen-induced arthritis of the rabbit temporomandibular joint

Miho Sukedai, Kazuhiro Tominaga, Manabu Habu, Akihiro Matsukawa, Tatsuji Nishihara, Jinichi Fukuda

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17 Citations (Scopus)


BACKGROUND: In temporomandibular joint (TMJ) arthritis, knowledge is limited about the source of the inflammatory mediators. The aim of this study was to investigate the immunohistochemical role of tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) in the development of the antigen-induced arthritis of the rabbit TMJ. METHODS: Unilateral TMJ arthritis was induced in 28 adult rabbits. From 6 h to 6 weeks after induction of arthritis, the topology of TNF-α and IL-8 was observed. RESULTS: Positive reaction for TNF-α of synovial cells was observed within 3 days after induction and at 3 weeks after induction. TNF-α positive vascular endothelial cells and chondrocytes were identified throughout the observation period. IL-8 was detected only during the acute stage. CONCLUSIONS: The cytokines TNF-α and IL-8 were observed in specific cells depending on the stage. TNF-α was particularly related with angiogenesis and cartilage destruction and IL-8 was involved in the acute stage of inflammation.

Original languageEnglish
Pages (from-to)102-110
Number of pages9
JournalJournal of Oral Pathology and Medicine
Issue number2
Publication statusPublished - Feb 1 2004



  • Antigen-induced arthritis
  • Immunohistochemistry
  • Interleukin-8
  • Rabbit
  • Temporomandibular joint
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

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