Involvement of the Vibrio parahaemolyticus pvsC gene in export of the siderophore vibrioferrin

Tomotaka Tanabe, Hiroshi Nakao, Teruo Kuroda, Tomofusa Tsuchiya, Shigeo Yamamoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The pvsC gene of unknown function has been found in the iron-regulated vibrioferrin biosynthesis operon of Vibrio parahaemolyticus (Tanabe, T. et al., J. Bacteriol. 185: 6938-6949, 2003). The amino acid sequence deduced from the gene showed significant similarity to 12-transmembrane segment efflux pumps belonging to the major facilitator superfamily. A nonpolar deletion of pvsC in V. parahaemolyticus resulted in a reduced release of vibrioferrin into the medium. Vibrioferrin release could be regained by introducing the intact pvsC gene on a complementing plasmid. These results indicate that the pvsC gene product functions as an inner membrane exporter of vibrioferrin.

Original languageEnglish
Pages (from-to)871-876
Number of pages6
JournalMICROBIOLOGY and IMMUNOLOGY
Volume50
Issue number11
Publication statusPublished - Nov 28 2006

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Keywords

  • Siderophore exporter
  • Vibrio parahaemolyticus
  • Vibrioferrin
  • pvsC

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

Cite this

Tanabe, T., Nakao, H., Kuroda, T., Tsuchiya, T., & Yamamoto, S. (2006). Involvement of the Vibrio parahaemolyticus pvsC gene in export of the siderophore vibrioferrin. MICROBIOLOGY and IMMUNOLOGY, 50(11), 871-876.